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Selective room-temperature hydrogenation of amides to amines and alcohols catalyzed by a ruthenium pincer complex and mechanistic insight

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Date
15/05/2020
Author
Kar, Sayan
Rauch, Michael
Kumar, Amit
Leitus, Gregory
Ben-David, Yehoshoa
Milstein, David
Keywords
Amide
Hydrogenation
Metal-ligand cooperation
Ruthenium-pincer
Room-tempature
Ruthenium amidate complex
QD Chemistry
DAS
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Abstract
We report a room-temperature protocol for the hydrogenation of various amides to produce amines and alcohols. Compared with most previous reports for this transformation, which use high temperatures (typically, 100–200 °C) and H2 pressures (10–100 bar), this system proceeds under extremely mild conditions (RT, 5–10 bar of H2). The hydrogenation is catalyzed by well-defined ruthenium-PNNH pincer complexes (0.5 mol %) with potential dual modes of metal–ligand cooperation. An unusual Ru-amidate complex was formed and crystallographically characterized. Mechanistic investigations indicate that the room-temperature hydrogenation proceeds predominantly via the Ru–N amido/amine metal–ligand cooperation.
Citation
Kar , S , Rauch , M , Kumar , A , Leitus , G , Ben-David , Y & Milstein , D 2020 , ' Selective room-temperature hydrogenation of amides to amines and alcohols catalyzed by a ruthenium pincer complex and mechanistic insight ' , ACS Catalysis , vol. 10 , no. 10 , pp. 5511-5515 . https://doi.org/10.1021/acscatal.0c01406
Publication
ACS Catalysis
Status
Peer reviewed
DOI
https://doi.org/10.1021/acscatal.0c01406
ISSN
2155-5435
Type
Journal article
Rights
Copyright © 2020 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Description
This research was supported by the European Research Council (ERC AdG 692775). D.M. holds the Israel Matz Professorial Chair of Organic Chemistry. S.K. acknowledges the Sustainability and Energy Research Initiative (SAERI) of the Weizmann Institute of Science for a research fellowship. M.R. acknowledges the Zuckerman STEM Leadership Program for a research fellowship.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/19862

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