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dc.contributor.authorWijesinghe, Philip
dc.contributor.authorJohansen, Niloufer J.
dc.contributor.authorCuratolo, Andrea
dc.contributor.authorSampson, David D.
dc.contributor.authorGanss, Ruth
dc.contributor.authorKennedy, Brendan F.
dc.contributor.editorSampson, David D.
dc.contributor.editorMatthews, Dennis L.
dc.contributor.editorPopp, Jurgen
dc.contributor.editorRubinsztein-Dunlop, Halina
dc.contributor.editorWilson, Brian C.
dc.date.accessioned2020-03-02T16:30:03Z
dc.date.available2020-03-02T16:30:03Z
dc.date.issued2017-04-29
dc.identifier266561240
dc.identifier24963703-11cd-48d9-a007-9a1d218e28d1
dc.identifier85020627475
dc.identifier.citationWijesinghe , P , Johansen , N J , Curatolo , A , Sampson , D D , Ganss , R & Kennedy , B F 2017 , Optical coherence elastography for cellular-scale stiffness imaging of mouse aorta . in D D Sampson , D L Matthews , J Popp , H Rubinsztein-Dunlop & B C Wilson (eds) , International Conference on Biophotonics V . , 1034010 , Progress in Biomedical Optics and Imaging - Proceedings of SPIE , vol. 10340 , SPIE , 5th International Conference on Biophotonics, ICOB 2017 , Perth , Western Australia , Australia , 30/04/17 . https://doi.org/10.1117/12.2269903en
dc.identifier.citationconferenceen
dc.identifier.isbn9781510611252
dc.identifier.isbn9781510611269
dc.identifier.issn1605-7422
dc.identifier.otherORCID: /0000-0002-8378-7261/work/69835204
dc.identifier.urihttps://hdl.handle.net/10023/19580
dc.description.abstractWe have developed a high-resolution optical coherence elastography system capable of estimating Young's modulus in tissue volumes with an isotropic resolution of 15 μm over a 1 mm lateral field of view and a 100 μm axial depth of field. We demonstrate our technique on healthy and hypertensive, freshly excised and intact mouse aortas. Our technique has the capacity to delineate the individual mechanics of elastic lamellae and vascular smooth muscle. Further, we observe global and regional vascular stiffening in hypertensive aortas, and note the presence of local micro-mechanical signatures, characteristic of fibrous and lipid-rich regions.
dc.format.extent1
dc.format.extent898114
dc.language.isoeng
dc.publisherSPIE
dc.relation.ispartofInternational Conference on Biophotonics Ven
dc.relation.ispartofseriesProgress in Biomedical Optics and Imaging - Proceedings of SPIEen
dc.subjectQC Physicsen
dc.subjectQH301 Biologyen
dc.subjectBiomaterialsen
dc.subjectElectronic, Optical and Magnetic Materialsen
dc.subjectRadiology Nuclear Medicine and imagingen
dc.subjectAtomic and Molecular Physics, and Opticsen
dc.subjectNSen
dc.subject.lccQCen
dc.subject.lccQH301en
dc.titleOptical coherence elastography for cellular-scale stiffness imaging of mouse aortaen
dc.typeConference itemen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.identifier.doi10.1117/12.2269903


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