Optical coherence elastography for cellular-scale stiffness imaging of mouse aorta
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We have developed a high-resolution optical coherence elastography system capable of estimating Young's modulus in tissue volumes with an isotropic resolution of 15 μm over a 1 mm lateral field of view and a 100 μm axial depth of field. We demonstrate our technique on healthy and hypertensive, freshly excised and intact mouse aortas. Our technique has the capacity to delineate the individual mechanics of elastic lamellae and vascular smooth muscle. Further, we observe global and regional vascular stiffening in hypertensive aortas, and note the presence of local micro-mechanical signatures, characteristic of fibrous and lipid-rich regions.
Wijesinghe , P , Johansen , N J , Curatolo , A , Sampson , D D , Ganss , R & Kennedy , B F 2017 , Optical coherence elastography for cellular-scale stiffness imaging of mouse aorta . in D D Sampson , D L Matthews , J Popp , H Rubinsztein-Dunlop & B C Wilson (eds) , International Conference on Biophotonics V . , 1034010 , Progress in Biomedical Optics and Imaging - Proceedings of SPIE , vol. 10340 , SPIE , 5th International Conference on Biophotonics, ICOB 2017 , Perth , Australia , 30/04/17 . https://doi.org/10.1117/12.2269903conference
International Conference on Biophotonics V
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