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dc.contributor.authorTreweek, Shaun
dc.contributor.authorBevan, Simon
dc.contributor.authorBower, Peter
dc.contributor.authorBriel, Matthias
dc.contributor.authorCampbell, Marion
dc.contributor.authorChristie, Jacquie
dc.contributor.authorCollett, Clive
dc.contributor.authorCotton, Seonaidh
dc.contributor.authorDevane, Declan
dc.contributor.authorEl Feky, Adel
dc.contributor.authorGalvin, Sandra
dc.contributor.authorGardner, Heidi
dc.contributor.authorGillies, Katie
dc.contributor.authorHood, Kerenza
dc.contributor.authorJansen, Jan
dc.contributor.authorLittleford, Roberta
dc.contributor.authorParker, Adwoa
dc.contributor.authorRamsay, Craig
dc.contributor.authorRestrup, Lynne
dc.contributor.authorSullivan, Frank
dc.contributor.authorTorgerson, David
dc.contributor.authorTremain, Liz
dc.contributor.authorvon Elm, Erik
dc.contributor.authorWestmore, Matthew
dc.contributor.authorWilliams, Hywel
dc.contributor.authorWilliamson, Paula R
dc.contributor.authorClarke, Mike
dc.identifier.citationTreweek , S , Bevan , S , Bower , P , Briel , M , Campbell , M , Christie , J , Collett , C , Cotton , S , Devane , D , El Feky , A , Galvin , S , Gardner , H , Gillies , K , Hood , K , Jansen , J , Littleford , R , Parker , A , Ramsay , C , Restrup , L , Sullivan , F , Torgerson , D , Tremain , L , von Elm , E , Westmore , M , Williams , H , Williamson , P R & Clarke , M 2020 , ' Trial Forge Guidance 2 : how to decide if a further Study Within A Trial (SWAT) is needed ' , Trials , vol. 21 , 33 .
dc.identifier.otherPubMedCentral: PMC6945587
dc.identifier.otherORCID: /0000-0002-6623-4964/work/67526037
dc.descriptionThe work described here was discussed at and after a meeting held in Aberdeen on 23 March 2017, which was funded by the Medical Research Council (MRC) Network of Hubs for Trials Methodology Research (Grant Reference: MR/L004933/1– B2) and the Health Research Board – Trials Methodology Research Network (Ireland).en
dc.description.abstractThe evidence base available to trialists to support trial process decisions—e.g. how best to recruit and retain participants, how to collect data or how to share the results with participants—is thin. One way to fill gaps in evidence is to run Studies Within A Trial, or SWATs. These are self-contained research studies embedded within a host trial that aim to evaluate or explore alternative ways of delivering or organising a particular trial process. SWATs are increasingly being supported by funders and considered by trialists, especially in the UK and Ireland. At some point, increasing SWAT evidence will lead funders and trialists to ask: given the current body of evidence for a SWAT, do we need a further evaluation in another host trial? A framework for answering such a question is needed to avoid SWATs themselves contributing to research waste. This paper presents criteria on when enough evidence is available for SWATs that use randomised allocation to compare different interventions.
dc.subjectRA Public aspects of medicineen
dc.titleTrial Forge Guidance 2 : how to decide if a further Study Within A Trial (SWAT) is neededen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.description.statusPeer revieweden

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