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Coagulatory defects in type-1 and type-2 diabetes

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dc.contributor.authorSobczak, Amelie Isabelle Sylvie
dc.contributor.authorStewart, Alan J.
dc.date.accessioned2019-12-16T15:30:10Z
dc.date.available2019-12-16T15:30:10Z
dc.date.issued2019-12-16
dc.identifier264321380
dc.identifiera4c7b140-2497-4b00-a2f0-f50817873555
dc.identifier85076911212
dc.identifier000506840100238
dc.identifier.citationSobczak , A I S & Stewart , A J 2019 , ' Coagulatory defects in type-1 and type-2 diabetes ' , International Journal of Molecular Sciences , vol. 20 , no. 24 , 6345 . https://doi.org/10.3390/ijms20246345en
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10023/19138
dc.descriptionThis research was funded by British Heart Foundation, grant numbers PG/15/9/31270 and FS/15/42/31556.en
dc.description.abstractDiabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.
dc.format.extent28
dc.format.extent2029565
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciencesen
dc.subjectAtherosclerosisen
dc.subjectEndothelial dysfunctionen
dc.subjectMagnesiumen
dc.subjectMetal ionsen
dc.subjectMicroparticlesen
dc.subjectPlateletsen
dc.subjectThrombosisen
dc.subjectZincen
dc.subjectQH301 Biologyen
dc.subjectRC Internal medicineen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQH301en
dc.subject.lccRCen
dc.titleCoagulatory defects in type-1 and type-2 diabetesen
dc.typeJournal itemen
dc.contributor.sponsorBritish Heart Foundationen
dc.contributor.sponsorBritish Heart Foundationen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.identifier.doihttps://doi.org/10.3390/ijms20246345
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.mdpi.com/1422-0067/20/24/6345en
dc.identifier.grantnumberPG/15/9/31270en
dc.identifier.grantnumberFS/15/42/31556en


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