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Coagulatory defects in type-1 and type-2 diabetes
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dc.contributor.author | Sobczak, Amelie Isabelle Sylvie | |
dc.contributor.author | Stewart, Alan J. | |
dc.date.accessioned | 2019-12-16T15:30:10Z | |
dc.date.available | 2019-12-16T15:30:10Z | |
dc.date.issued | 2019-12-16 | |
dc.identifier | 264321380 | |
dc.identifier | a4c7b140-2497-4b00-a2f0-f50817873555 | |
dc.identifier | 85076911212 | |
dc.identifier | 000506840100238 | |
dc.identifier.citation | Sobczak , A I S & Stewart , A J 2019 , ' Coagulatory defects in type-1 and type-2 diabetes ' , International Journal of Molecular Sciences , vol. 20 , no. 24 , 6345 . https://doi.org/10.3390/ijms20246345 | en |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | https://hdl.handle.net/10023/19138 | |
dc.description | This research was funded by British Heart Foundation, grant numbers PG/15/9/31270 and FS/15/42/31556. | en |
dc.description.abstract | Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes. | |
dc.format.extent | 28 | |
dc.format.extent | 2029565 | |
dc.language.iso | eng | |
dc.relation.ispartof | International Journal of Molecular Sciences | en |
dc.subject | Atherosclerosis | en |
dc.subject | Endothelial dysfunction | en |
dc.subject | Magnesium | en |
dc.subject | Metal ions | en |
dc.subject | Microparticles | en |
dc.subject | Platelets | en |
dc.subject | Thrombosis | en |
dc.subject | Zinc | en |
dc.subject | QH301 Biology | en |
dc.subject | RC Internal medicine | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | RC | en |
dc.title | Coagulatory defects in type-1 and type-2 diabetes | en |
dc.type | Journal item | en |
dc.contributor.sponsor | British Heart Foundation | en |
dc.contributor.sponsor | British Heart Foundation | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. Cellular Medicine Division | en |
dc.identifier.doi | 10.3390/ijms20246345 | |
dc.description.status | Peer reviewed | en |
dc.identifier.url | https://www.mdpi.com/1422-0067/20/24/6345 | en |
dc.identifier.grantnumber | PG/15/9/31270 | en |
dc.identifier.grantnumber | FS/15/42/31556 | en |
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