Coagulatory defects in type-1 and type-2 diabetes
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Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.
Sobczak , A I S & Stewart , A J 2019 , ' Coagulatory defects in type-1 and type-2 diabetes ' , International Journal of Molecular Sciences , vol. 20 , no. 24 , 6345 . https://doi.org/10.3390/ijms20246345
International Journal of Molecular Sciences
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DescriptionThis research was funded by British Heart Foundation, grant numbers PG/15/9/31270 and FS/15/42/31556.
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