Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions
Abstract
Blending synthetic chemistry and biology is synthetically powerful. To further enable this, compatible synthetic tools are needed. We report the first Buchwald Hartwig amination reactions with unprotected halotryptophans in aqueous systems and demonstrate this methodology applicable to the modification of unprotected halotryptophans, simple tripeptides and the natural product barettin.
Citation
Renault , Y J G , Lynch , R , Marelli , E , Sharma , S V , Pubill Ulldemolins , C , Sharp , J , Cartmell , C , Cárdenas , P & Goss , R J M 2019 , ' Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions ' , Chemical Communications , vol. Advance Article . https://doi.org/10.1039/C9CC02554E
Publication
Chemical Communications
Status
Peer reviewed
ISSN
1359-7345Type
Journal item
Description
The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013/ERC grant agreement no 614779 GenoChemetics (to R.J.M.G) P. Cárdenas received support from the European Union's Horizon 2020 research and innovation program through the SponGES project (grant agreement No. 679849).Collections
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