Formal synthesis of (+)-lactacystin from L-serine
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A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-L-serine, providing the key intermediate 13 , also useful for the generation of a range of C-9 analogues.
Page , P C B , Goodyear , R L , Chan , Y , Slawin , A M Z & Allin , S M 2019 , ' Formal synthesis of (+)-lactacystin from L-serine ' , RSC Advances , vol. 9 , no. 51 , pp. 30019-30032 . https://doi.org/10.1039/c9ra07244f
Copyright © 2019 The Author(s). Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
DescriptionThis investigation has enjoyed the support of Charnwood Molecular Ltd and the University of East Anglia.
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