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Dimethylisosorbide (DMI) as a bio-derived solvent for Pd-catalyzed cross-coupling reactions

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dc.contributor.authorWilson, Kirsty L.
dc.contributor.authorMurray, Jane
dc.contributor.authorSneddon, Helen
dc.contributor.authorJamieson, Craig
dc.contributor.authorWatson, Allan J. B.
dc.date.accessioned2019-09-27T23:37:32Z
dc.date.available2019-09-27T23:37:32Z
dc.date.issued2018-10
dc.identifier255931977
dc.identifier8f83a73d-8767-423e-ab99-6c7fa62940dd
dc.identifier85054825730
dc.identifier000446716600013
dc.identifier.citationWilson , K L , Murray , J , Sneddon , H , Jamieson , C & Watson , A J B 2018 , ' Dimethylisosorbide (DMI) as a bio-derived solvent for Pd-catalyzed cross-coupling reactions ' , Synlett , vol. 29 , no. 17 , pp. 2293-2297 . https://doi.org/10.1055/s-0037-1611054en
dc.identifier.issn0936-5214
dc.identifier.otherORCID: /0000-0002-1582-4286/work/56639184
dc.identifier.urihttps://hdl.handle.net/10023/18572
dc.descriptionThe authors thank the University of Strathclyde for a PhD studentship (KLW) and Merck KGaA, Darmstadt, Germany, for financial and material support.en
dc.description.abstractPalladium-catalyzed bond forming reactions, such as the SuzukiMiyaura and Mizoroki-Heck reactions, are some of the most broadly utilized reactions within the chemical industry. These reactions frequently employ hazardous solvents; however, to adhere to increasing sustainability pressures and restrictions regarding the use of such solvents, alternatives are highly sought after. Here we demonstrate the utility of dimethyl isosorbide (DMI) as a bio-derived solvent in several benchmark Pd-catalysed reactions: Suzuki– Miyaura (13 examples, 62–100% yield), Mizoroki–Heck (13 examples, 47– 91% yield), and Sonogashira (12 examples, 65–98% yield).
dc.format.extent5
dc.format.extent659060
dc.language.isoeng
dc.relation.ispartofSynletten
dc.subjectCross-couplingen
dc.subjectGreen chemistryen
dc.subjectPalladiumen
dc.subjectSolventsen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleDimethylisosorbide (DMI) as a bio-derived solvent for Pd-catalyzed cross-coupling reactionsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.identifier.doi10.1055/s-0037-1611054
dc.description.statusPeer revieweden
dc.date.embargoedUntil2019-09-28


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