Dimethylisosorbide (DMI) as a bio-derived solvent for Pd-catalyzed cross-coupling reactions
Date
10/2018Metadata
Show full item recordAbstract
Palladium-catalyzed bond forming reactions, such as the SuzukiMiyaura and Mizoroki-Heck reactions, are some of the most broadly utilized reactions within the chemical industry. These reactions frequently employ hazardous solvents; however, to adhere to increasing sustainability pressures and restrictions regarding the use of such solvents, alternatives are highly sought after. Here we demonstrate the utility of dimethyl isosorbide (DMI) as a bio-derived solvent in several benchmark Pd-catalysed reactions: Suzuki– Miyaura (13 examples, 62–100% yield), Mizoroki–Heck (13 examples, 47– 91% yield), and Sonogashira (12 examples, 65–98% yield).
Citation
Wilson , K L , Murray , J , Sneddon , H , Jamieson , C & Watson , A J B 2018 , ' Dimethylisosorbide (DMI) as a bio-derived solvent for Pd-catalyzed cross-coupling reactions ' , Synlett , vol. 29 , no. 17 , pp. 2293-2297 . https://doi.org/10.1055/s-0037-1611054
Publication
Synlett
Status
Peer reviewed
ISSN
0936-5214Type
Journal article
Rights
Copyright © 2018 Georg Thieme Verlag Stuttgart, New York. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1055/s-0037-1611054
Description
The authors thank the University of Strathclyde for a PhD studentship (KLW) and Merck KGaA, Darmstadt, Germany, for financial and material support.Collections
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