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Biocatalytic synthesis of chiral N-functionalized amino acids
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dc.contributor.author | Hyslop, Julia | |
dc.contributor.author | Lovelock, Sarah L | |
dc.contributor.author | Sutton, Peter | |
dc.contributor.author | Brown, Kristin K | |
dc.contributor.author | Watson, Allan J. B. | |
dc.contributor.author | Roiban, Gheorghe-Doru | |
dc.date.accessioned | 2019-09-20T23:38:35Z | |
dc.date.available | 2019-09-20T23:38:35Z | |
dc.date.issued | 2018-09-21 | |
dc.identifier | 255579802 | |
dc.identifier | b377e165-5d41-4071-ac8b-c0b22697e39e | |
dc.identifier | 85053700372 | |
dc.identifier | 000446826200016 | |
dc.identifier.citation | Hyslop , J , Lovelock , S L , Sutton , P , Brown , K K , Watson , A J B & Roiban , G-D 2018 , ' Biocatalytic synthesis of chiral N-functionalized amino acids ' , Angewandte Chemie International Edition , vol. Early View . https://doi.org/10.1002/anie.201806893 | en |
dc.identifier.issn | 1433-7851 | |
dc.identifier.other | RIS: urn:9F21E6CBAA2CDC6D0339290A79132F97 | |
dc.identifier.other | ORCID: /0000-0002-1582-4286/work/56639167 | |
dc.identifier.uri | https://hdl.handle.net/10023/18531 | |
dc.description.abstract | N-functionalized amino acids are important building blocks for the preparation of diverse bioactive molecules including peptides. The development of sustainable manufacturing routes to chiral N-alkylated amino acids remains a significant challenge in the pharmaceutical and fine chemical industries. Herein we report the discovery of a structurally diverse panel of biocatalysts which catalyze the asymmetric synthesis of N-alkyl amino acids via the reductive coupling of ketones and amines. Reactions have been performed on a gram scale to yield optically pure N-alkyl functionalized products in high yields. | |
dc.format.extent | 1126871 | |
dc.language.iso | eng | |
dc.relation.ispartof | Angewandte Chemie International Edition | en |
dc.subject | N-methyl amino acid deyhydrogenases | en |
dc.subject | Ketimine reductases | en |
dc.subject | α-keto amino acids | en |
dc.subject | Biocatalysis | en |
dc.subject | Reductive amination | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject | SDG 9 - Industry, Innovation, and Infrastructure | en |
dc.subject.lcc | QD | en |
dc.title | Biocatalytic synthesis of chiral N-functionalized amino acids | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.identifier.doi | https://doi.org/10.1002/anie.201806893 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2019-09-21 |
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