Biocatalytic synthesis of chiral N-functionalized amino acids
Abstract
N-functionalized amino acids are important building blocks for the preparation of diverse bioactive molecules including peptides. The development of sustainable manufacturing routes to chiral N-alkylated amino acids remains a significant challenge in the pharmaceutical and fine chemical industries. Herein we report the discovery of a structurally diverse panel of biocatalysts which catalyze the asymmetric synthesis of N-alkyl amino acids via the reductive coupling of ketones and amines. Reactions have been performed on a gram scale to yield optically pure N-alkyl functionalized products in high yields.
Citation
Hyslop , J , Lovelock , S L , Sutton , P , Brown , K K , Watson , A J B & Roiban , G-D 2018 , ' Biocatalytic synthesis of chiral N-functionalized amino acids ' , Angewandte Chemie International Edition , vol. Early View . https://doi.org/10.1002/anie.201806893
Publication
Angewandte Chemie International Edition
Status
Peer reviewed
ISSN
1433-7851Type
Journal article
Collections
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