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dc.contributor.authorLiu, Yang
dc.contributor.authorvan den Wildenberg, Wery P.M.
dc.contributor.authorde Graaf, Ysanne
dc.contributor.authorAmes, Susan L.
dc.contributor.authorBaldacchino, Alexander
dc.contributor.authorBø, Ragnhild
dc.contributor.authorCadaveira, Fernando
dc.contributor.authorCampanella, Salvatore
dc.contributor.authorChristiansen, Paul
dc.contributor.authorClaus, Eric D.
dc.contributor.authorColzato, Lorenzo S.
dc.contributor.authorFilbey, Francesca M.
dc.contributor.authorFoxe, John J.
dc.contributor.authorGaravan, Hugh
dc.contributor.authorHendershot, Christian S.
dc.contributor.authorHester, Robert
dc.contributor.authorJester, Jennifer M.
dc.contributor.authorKaroly, Hollis C.
dc.contributor.authorKräplin, Anja
dc.contributor.authorKreusch, Fanny
dc.contributor.authorLandrø, Nils Inge
dc.contributor.authorLittel, Marianne
dc.contributor.authorSteins-Löber, Sabine
dc.contributor.authorLondon, Edythe D.
dc.contributor.authorLópez-Caneda, Eduardo
dc.contributor.authorLubman, Dan I.
dc.contributor.authorLuijten, Maartje
dc.contributor.authorMarczinski, Cecile A.
dc.contributor.authorMetrik, Jane
dc.contributor.authorMontgomery, Catharine
dc.contributor.authorPapachristou, Harilaos
dc.contributor.authorPark, Su Mi
dc.contributor.authorPaz, Andres L.
dc.contributor.authorPetit, Géraldine
dc.contributor.authorPrisciandaro, James J.
dc.contributor.authorQuednow, Boris B.
dc.contributor.authorRay, Lara A.
dc.contributor.authorRoberts, Carl A.
dc.contributor.authorRoberts, Gloria M.P.
dc.contributor.authorde Ruiter, Michael B.
dc.contributor.authorRupp, Claudia I.
dc.contributor.authorSteele, Vaughn R.
dc.contributor.authorSun, Delin
dc.contributor.authorTakagi, Michael
dc.contributor.authorTapert, Susan F.
dc.contributor.authorvan Holst, Ruth J.
dc.contributor.authorVerdejo-Garcia, Antonio
dc.contributor.authorVonmoos, Matthias
dc.contributor.authorWojnar, Marcin
dc.contributor.authorYao, Yuanwei
dc.contributor.authorYücel, Murat
dc.contributor.authorZack, Martin
dc.contributor.authorZucker, Robert A.
dc.contributor.authorHuizenga, Hilda M.
dc.contributor.authorWiers, Reinout W.
dc.identifier.citationLiu , Y , van den Wildenberg , W P M , de Graaf , Y , Ames , S L , Baldacchino , A , Bø , R , Cadaveira , F , Campanella , S , Christiansen , P , Claus , E D , Colzato , L S , Filbey , F M , Foxe , J J , Garavan , H , Hendershot , C S , Hester , R , Jester , J M , Karoly , H C , Kräplin , A , Kreusch , F , Landrø , N I , Littel , M , Steins-Löber , S , London , E D , López-Caneda , E , Lubman , D I , Luijten , M , Marczinski , C A , Metrik , J , Montgomery , C , Papachristou , H , Park , S M , Paz , A L , Petit , G , Prisciandaro , J J , Quednow , B B , Ray , L A , Roberts , C A , Roberts , G M P , de Ruiter , M B , Rupp , C I , Steele , V R , Sun , D , Takagi , M , Tapert , S F , van Holst , R J , Verdejo-Garcia , A , Vonmoos , M , Wojnar , M , Yao , Y , Yücel , M , Zack , M , Zucker , R A , Huizenga , H M & Wiers , R W 2019 , ' Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders ' , Neuroscience and Biobehavioral Reviews , vol. 105 , pp. 288-304 .
dc.identifier.otherPURE: 259538886
dc.identifier.otherPURE UUID: 598881de-9822-482e-9107-8b23e3e4e19b
dc.identifier.otherORCID: /0000-0002-5388-7376/work/60196761
dc.identifier.otherScopus: 85070721793
dc.identifier.otherWOS: 000487573500026
dc.descriptionYang Liu thanks the China scholarship council (CSC) (No. 201506990019) for fellowship support. HMH is supported by a VICI grant awarded by the Netherlands Organization of Scientific Research (NWO) [grant number 453-12-005]. MY was supported by a National Health and Medical Research Council of Australia Fellowship (#APP1117188) and the David Winston Turner Endowment Fund.en
dc.description.abstractMany studies have reported that heavy substance use is associated with impaired response inhibition. Studies typically focused on associations with a single substance, while polysubstance use is common. Further, most studies compared heavy users with light/non-users, though substance use occurs along a continuum. The current mega-analysis accounted for these issues by aggregating individual data from 43 studies (3610 adult participants) that used the Go/No-Go (GNG) or Stop-signal task (SST) to assess inhibition among mostly “recreational” substance users (i.e., the rate of substance use disorders was low). Main and interaction effects of substance use, demographics, and task-characteristics were entered in a linear mixed model. Contrary to many studies and reviews in the field, we found that only lifetime cannabis use was associated with impaired response inhibition in the SST. An interaction effect was also observed: the relationship between tobacco use and response inhibition (in the SST) differed between cannabis users and non-users, with a negative association between tobacco use and inhibition in the cannabis non-users. In addition, participants’ age, education level, and some task characteristics influenced inhibition outcomes. Overall, we found limited support for impaired inhibition among substance users when controlling for demographics and task-characteristics.
dc.relation.ispartofNeuroscience and Biobehavioral Reviewsen
dc.rightsCopyright 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (
dc.subjectPolysubstance useen
dc.subjectResponse inhibitionen
dc.subjectStop-signal tasken
dc.subjectGo/No-Go tasken
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleIs (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confoundersen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews. Centre for Minorities Research (CMR)en
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.description.statusPeer revieweden

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