Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders
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Many studies have reported that heavy substance use is associated with impaired response inhibition. Studies typically focused on associations with a single substance, while polysubstance use is common. Further, most studies compared heavy users with light/non-users, though substance use occurs along a continuum. The current mega-analysis accounted for these issues by aggregating individual data from 43 studies (3610 adult participants) that used the Go/No-Go (GNG) or Stop-signal task (SST) to assess inhibition among mostly “recreational” substance users (i.e., the rate of substance use disorders was low). Main and interaction effects of substance use, demographics, and task-characteristics were entered in a linear mixed model. Contrary to many studies and reviews in the field, we found that only lifetime cannabis use was associated with impaired response inhibition in the SST. An interaction effect was also observed: the relationship between tobacco use and response inhibition (in the SST) differed between cannabis users and non-users, with a negative association between tobacco use and inhibition in the cannabis non-users. In addition, participants’ age, education level, and some task characteristics influenced inhibition outcomes. Overall, we found limited support for impaired inhibition among substance users when controlling for demographics and task-characteristics.
Liu , Y , van den Wildenberg , W P M , de Graaf , Y , Ames , S L , Baldacchino , A , Bø , R , Cadaveira , F , Campanella , S , Christiansen , P , Claus , E D , Colzato , L S , Filbey , F M , Foxe , J J , Garavan , H , Hendershot , C S , Hester , R , Jester , J M , Karoly , H C , Kräplin , A , Kreusch , F , Landrø , N I , Littel , M , Steins-Löber , S , London , E D , López-Caneda , E , Lubman , D I , Luijten , M , Marczinski , C A , Metrik , J , Montgomery , C , Papachristou , H , Park , S M , Paz , A L , Petit , G , Prisciandaro , J J , Quednow , B B , Ray , L A , Roberts , C A , Roberts , G M P , de Ruiter , M B , Rupp , C I , Steele , V R , Sun , D , Takagi , M , Tapert , S F , van Holst , R J , Verdejo-Garcia , A , Vonmoos , M , Wojnar , M , Yao , Y , Yücel , M , Zack , M , Zucker , R A , Huizenga , H M & Wiers , R W 2019 , ' Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders ' , Neuroscience and Biobehavioral Reviews , vol. 105 , pp. 288-304 . https://doi.org/10.1016/j.neubiorev.2019.07.006
Neuroscience and Biobehavioral Reviews
Copyright 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
DescriptionYang Liu thanks the China scholarship council (CSC) (No. 201506990019) for fellowship support. HMH is supported by a VICI grant awarded by the Netherlands Organization of Scientific Research (NWO) [grant number 453-12-005]. MY was supported by a National Health and Medical Research Council of Australia Fellowship (#APP1117188) and the David Winston Turner Endowment Fund.
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