Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.authorClark, Marcia E
dc.contributor.authorBedford, Laura E
dc.contributor.authorYoung, Ben
dc.contributor.authorRobertson, John FR
dc.contributor.authorNair, Roshan das
dc.contributor.authorVedhara, Kavita
dc.contributor.authorLittleford, Roberta
dc.contributor.authorSullivan, Francis M
dc.contributor.authorMair, Frances S
dc.contributor.authorSchembri, Stuart
dc.contributor.authorRauchhaus, Petra
dc.contributor.authorKendrick, Denise
dc.date.accessioned2019-08-02T23:43:24Z
dc.date.available2019-08-02T23:43:24Z
dc.date.issued2018-10
dc.identifier255208090
dc.identifierd76d5318-9aed-4d0f-a32c-1aa213116cc9
dc.identifier85051467562
dc.identifier000448100600025
dc.identifier85051467562
dc.identifier30268456
dc.identifier.citationClark , M E , Bedford , L E , Young , B , Robertson , J FR , Nair , R D , Vedhara , K , Littleford , R , Sullivan , F M , Mair , F S , Schembri , S , Rauchhaus , P & Kendrick , D 2018 , ' Lung cancer CT screening : psychological responses in the presence and absence of pulmonary nodules ' , Lung Cancer , vol. 124 , pp. 160-167 . https://doi.org/10.1016/j.lungcan.2018.08.001en
dc.identifier.issn0169-5002
dc.identifier.otherRIS: urn:73E43634ACFD014FFB56E30C98B9DAB6
dc.identifier.otherORCID: /0000-0002-6623-4964/work/47356695
dc.identifier.urihttps://hdl.handle.net/10023/18239
dc.descriptionThis study was carried out as part of a National Institute for Health Research (NIHR) School for Primary Care Research (SPCR) funded academic clinical fellowship. The ECLS study was funded by the Scottish Executive and Oncimmune Ltd. The follow-up data collection was funded by University of Nottingham PhD studentships and by Oncimmune Ltd.en
dc.description.abstractObjectives: To determine the psychological response (thoughts, perceptions and affect) to a diagnosis of pulmonary nodules following a novel antibody blood test and computed tomography (CT) scans within a UK population. Materials and methods: This study was nested within a randomised controlled trial of a blood test (Early CDT®-Lung test), followed by a chest x-ray and serial CT-scanning of those with a positive blood test for early detection of lung cancer (ECLS Study). Trial participants with a positive Early CDT®-Lung test were invited to participate (n = 338) and those agreeing completed questionnaires assessing psychological outcomes at 1, 3 and 6 months following trial recruitment. Responses of individuals with pulmonary nodules on their first CT scan were compared to those without (classified as normal CT) at 3 and 6 months follow-up using random effects regression models to account for multiple observations per participant, with loge transformation of data where modelling assumptions were not met. Results: There were no statistically significant differences between the nodule and normal CT groups in affect, lung cancer worry, health anxiety, illness perceptions, lung cancer risk perception or intrusive thoughts at 3 or 6 months post-recruitment. The nodule group had statistically significantly fewer avoidance symptoms compared to the normal CT group at 3 months (impact of events scale avoidance (IES-A) difference between means -1.99, 95%CI -4.18, 0.21) than at 6 months (IES-A difference between means 0.88, 95%CI -1.32, 3.08; p-value for change over time = 0.003) with similar findings using loge transformed data. Conclusion: A diagnosis of pulmonary nodules following an Early CDT®-Lung test and CT scan did not appear to result in adverse psychological responses compared to those with a normal CT scan.
dc.format.extent8
dc.format.extent524628
dc.language.isoeng
dc.relation.ispartofLung Canceren
dc.subjectPulmonary nodulesen
dc.subjectLung cancer screeningen
dc.subjectPsychological impacten
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectCancer Researchen
dc.subjectOncologyen
dc.subjectPulmonary and Respiratory Medicineen
dc.subjectNDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRC0254en
dc.titleLung cancer CT screening : psychological responses in the presence and absence of pulmonary nodulesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.identifier.doi10.1016/j.lungcan.2018.08.001
dc.description.statusPeer revieweden
dc.date.embargoedUntil2019-08-03


This item appears in the following Collection(s)

Show simple item record