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Lung cancer CT screening : psychological responses in the presence and absence of pulmonary nodules
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dc.contributor.author | Clark, Marcia E | |
dc.contributor.author | Bedford, Laura E | |
dc.contributor.author | Young, Ben | |
dc.contributor.author | Robertson, John FR | |
dc.contributor.author | Nair, Roshan das | |
dc.contributor.author | Vedhara, Kavita | |
dc.contributor.author | Littleford, Roberta | |
dc.contributor.author | Sullivan, Francis M | |
dc.contributor.author | Mair, Frances S | |
dc.contributor.author | Schembri, Stuart | |
dc.contributor.author | Rauchhaus, Petra | |
dc.contributor.author | Kendrick, Denise | |
dc.date.accessioned | 2019-08-02T23:43:24Z | |
dc.date.available | 2019-08-02T23:43:24Z | |
dc.date.issued | 2018-10 | |
dc.identifier | 255208090 | |
dc.identifier | d76d5318-9aed-4d0f-a32c-1aa213116cc9 | |
dc.identifier | 85051467562 | |
dc.identifier | 000448100600025 | |
dc.identifier | 85051467562 | |
dc.identifier | 30268456 | |
dc.identifier.citation | Clark , M E , Bedford , L E , Young , B , Robertson , J FR , Nair , R D , Vedhara , K , Littleford , R , Sullivan , F M , Mair , F S , Schembri , S , Rauchhaus , P & Kendrick , D 2018 , ' Lung cancer CT screening : psychological responses in the presence and absence of pulmonary nodules ' , Lung Cancer , vol. 124 , pp. 160-167 . https://doi.org/10.1016/j.lungcan.2018.08.001 | en |
dc.identifier.issn | 0169-5002 | |
dc.identifier.other | RIS: urn:73E43634ACFD014FFB56E30C98B9DAB6 | |
dc.identifier.other | ORCID: /0000-0002-6623-4964/work/47356695 | |
dc.identifier.uri | https://hdl.handle.net/10023/18239 | |
dc.description | This study was carried out as part of a National Institute for Health Research (NIHR) School for Primary Care Research (SPCR) funded academic clinical fellowship. The ECLS study was funded by the Scottish Executive and Oncimmune Ltd. The follow-up data collection was funded by University of Nottingham PhD studentships and by Oncimmune Ltd. | en |
dc.description.abstract | Objectives: To determine the psychological response (thoughts, perceptions and affect) to a diagnosis of pulmonary nodules following a novel antibody blood test and computed tomography (CT) scans within a UK population. Materials and methods: This study was nested within a randomised controlled trial of a blood test (Early CDT®-Lung test), followed by a chest x-ray and serial CT-scanning of those with a positive blood test for early detection of lung cancer (ECLS Study). Trial participants with a positive Early CDT®-Lung test were invited to participate (n = 338) and those agreeing completed questionnaires assessing psychological outcomes at 1, 3 and 6 months following trial recruitment. Responses of individuals with pulmonary nodules on their first CT scan were compared to those without (classified as normal CT) at 3 and 6 months follow-up using random effects regression models to account for multiple observations per participant, with loge transformation of data where modelling assumptions were not met. Results: There were no statistically significant differences between the nodule and normal CT groups in affect, lung cancer worry, health anxiety, illness perceptions, lung cancer risk perception or intrusive thoughts at 3 or 6 months post-recruitment. The nodule group had statistically significantly fewer avoidance symptoms compared to the normal CT group at 3 months (impact of events scale avoidance (IES-A) difference between means -1.99, 95%CI -4.18, 0.21) than at 6 months (IES-A difference between means 0.88, 95%CI -1.32, 3.08; p-value for change over time = 0.003) with similar findings using loge transformed data. Conclusion: A diagnosis of pulmonary nodules following an Early CDT®-Lung test and CT scan did not appear to result in adverse psychological responses compared to those with a normal CT scan. | |
dc.format.extent | 8 | |
dc.format.extent | 524628 | |
dc.language.iso | eng | |
dc.relation.ispartof | Lung Cancer | en |
dc.subject | Pulmonary nodules | en |
dc.subject | Lung cancer screening | en |
dc.subject | Psychological impact | en |
dc.subject | RC0254 Neoplasms. Tumors. Oncology (including Cancer) | en |
dc.subject | Cancer Research | en |
dc.subject | Oncology | en |
dc.subject | Pulmonary and Respiratory Medicine | en |
dc.subject | NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RC0254 | en |
dc.title | Lung cancer CT screening : psychological responses in the presence and absence of pulmonary nodules | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Population and Behavioural Science Division | en |
dc.identifier.doi | 10.1016/j.lungcan.2018.08.001 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2019-08-03 |
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