Deciphering the genomic, epigenomic and transcriptomic landscapes of pre-invasive lung cancer lesions
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The molecular alterations that occur in cells before cancer is manifest are largely uncharted. Lung carcinoma in situ (CIS) lesions are the pre-invasive precursor to squamous cell carcinoma. Although microscopically identical, their future is in equipoise, with half progressing to invasive cancer and half regressing or remaining static. The cellular basis of this clinical observation is unknown. Here, we profile the genomic, transcriptomic, and epigenomic landscape of CIS in a unique patient cohort with longitudinally monitored pre-invasive disease. Predictive modeling identifies which lesions will progress with remarkable accuracy. We identify progression-specific methylation changes on a background of widespread heterogeneity, alongside a strong chromosomal instability signature. We observed mutations and copy number changes characteristic of cancer and chart their emergence, offering a window into early carcinogenesis. We anticipate that this new understanding of cancer precursor biology will improve early detection, reduce overtreatment, and foster preventative therapies targeting early clonal events in lung cancer.
Texeira , V H , Pipinikas , C P , Pennycuick , A , Lee-Six , H , Chandrasekharan , D , Beane , J , Morris , T J , Karpathakis , A , Feber , A , Breeze , C E , Ntolios , P , Hynds , R E , Falzon , M , Capitanio , A , Carroll , B , Durrenberger , P F , Hardavella , G , Brown , J M , Lynch , A G , Farmery , H , Paul , D S , Chambers , R C , McGranahan , N , Navani , N , Thakrar , R M , Swanton , C , Beck , S , George , P J , Spira , A , Campbell , P J , Thirwell , C & Janes , S M 2019 , ' Deciphering the genomic, epigenomic and transcriptomic landscapes of pre-invasive lung cancer lesions ' , Nature Medicine , vol. 25 , no. 3 , pp. 517-525 . https://doi.org/10.1038/s41591-018-0323-0
Copyright © 2019, the Author(s). This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1038/s41591-018-0323-0
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