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Visible light-promoted iron-catalyzed C(sp2)-C(sp3) Kumada cross-coupling in flow
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dc.contributor.author | Wei, Xiao-Jing | |
dc.contributor.author | Abdiaj, Irini | |
dc.contributor.author | Sambiagio, Carlo | |
dc.contributor.author | Li, Chenfei | |
dc.contributor.author | Zysman-Colman, Eli | |
dc.contributor.author | Alcázar, Jesús | |
dc.contributor.author | Noël, Timothy | |
dc.date.accessioned | 2019-07-12T10:30:01Z | |
dc.date.available | 2019-07-12T10:30:01Z | |
dc.date.issued | 2019-09-05 | |
dc.identifier | 259377844 | |
dc.identifier | 8ebe6868-1c8a-444b-b64c-0d034d5d7d71 | |
dc.identifier | 000474898200001 | |
dc.identifier | 85068901897 | |
dc.identifier.citation | Wei , X-J , Abdiaj , I , Sambiagio , C , Li , C , Zysman-Colman , E , Alcázar , J & Noël , T 2019 , ' Visible light-promoted iron-catalyzed C(sp 2 )-C(sp 3 ) Kumada cross-coupling in flow ' , Angewandte Chemie International Edition , vol. 58 , no. 37 , pp. 13030-13034 . https://doi.org/10.1002/anie.201906462 | en |
dc.identifier.issn | 1433-7851 | |
dc.identifier.other | ORCID: /0000-0001-7183-6022/work/62668445 | |
dc.identifier.uri | https://hdl.handle.net/10023/18092 | |
dc.description | X.-J.W., I.A., J.A., and T.N. would like to acknowledge the European Union for a Marie Curie ITN Grant (Photo4Future, Grant No. 641861). C.S. acknowledges the European Union for a Marie Curie European post-doctoral fellowship (FlowAct, Grant No. 794072). We would like to thank the Engineering and Physical Sciences Research Council for financial support (EP/M02105X/1). C. L. thanks the Prof. & Mrs Purdie Bequests Scholarship and AstraZeneca for his PhD Studentship. | en |
dc.description.abstract | A continuous‐flow, visible‐light‐promoted method has been developed to overcome the limitations of iron‐catalyzed Kumada–Corriu cross‐coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes’ residence time, considerably enhancing the applicability of this iron‐catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application. | |
dc.format.extent | 6 | |
dc.format.extent | 2746505 | |
dc.language.iso | eng | |
dc.relation.ispartof | Angewandte Chemie International Edition | en |
dc.subject | Cross-coupling | en |
dc.subject | Iron catalysis | en |
dc.subject | Photocatalysis | en |
dc.subject | Kumada coupling | en |
dc.subject | Flow chemistry | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject | BDC | en |
dc.subject.lcc | QD | en |
dc.title | Visible light-promoted iron-catalyzed C(sp2)-C(sp3) Kumada cross-coupling in flow | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Organic Semiconductor Centre | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | https://doi.org/10.1002/anie.201906462 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | EP/M02105X/1 | en |
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