Visible light-promoted iron-catalyzed C(sp2)-C(sp3) Kumada cross-coupling in flow
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A continuous‐flow, visible‐light‐promoted method has been developed to overcome the limitations of iron‐catalyzed Kumada–Corriu cross‐coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes’ residence time, considerably enhancing the applicability of this iron‐catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application.
Wei , X-J , Abdiaj , I , Sambiagio , C , Li , C , Zysman-Colman , E , Alcázar , J & Noël , T 2019 , ' Visible light-promoted iron-catalyzed C(sp 2 )-C(sp 3 ) Kumada cross-coupling in flow ' , Angewandte Chemie International Edition , vol. 58 , no. 37 , pp. 13030-13034 . https://doi.org/10.1002/anie.201906462
Angewandte Chemie International Edition
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DescriptionX.-J.W., I.A., J.A., and T.N. would like to acknowledge the European Union for a Marie Curie ITN Grant (Photo4Future, Grant No. 641861). C.S. acknowledges the European Union for a Marie Curie European post-doctoral fellowship (FlowAct, Grant No. 794072). We would like to thank the Engineering and Physical Sciences Research Council for financial support (EP/M02105X/1). C. L. thanks the Prof. & Mrs Purdie Bequests Scholarship and AstraZeneca for his PhD Studentship.
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