Visible light-promoted Fe-catalyzed C(sp2)-C(sp3) Kumada cross-coupling in flow
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A continuous-flow, visible light-promoted method has been developed to overcome the limitations of Fe-catalyzed Kumada-Corriu cross-couplings. A variety of strongly electron-rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature, in high yields and within a few minutes residence time, considerably enhancing the applicability of this Fe-catalyzed reaction. The robustness of this protocol was demonstrated on the multi-gram scale, providing the potential for future pharmaceutical application.
Wei , X-J , Abdiaj , I , Sambiagio , C , Li , C , Zysman-Colman , E , Alcázar , J & Noël , T 2019 , ' Visible light-promoted Fe-catalyzed C(sp 2 )-C(sp 3 ) Kumada cross-coupling in flow ' Angewandte Chemie International Edition , vol. Early View . https://doi.org/10.1002/anie.201906462
Angewandte Chemie International Edition
Copyright © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
DescriptionX.-J.W., I.A., J.A., and T.N. would like to acknowledge the European Union for a Marie Curie ITN Grant (Photo4Future, Grant No. 641861). C.S. acknowledges the European Union for a Marie Curie European post-doctoral fellowship (FlowAct, Grant No. 794072). We would like to thank the Engineering and Physical Sciences Research Council for financial support (EP/M02105X/1). C. L. thanks the Prof. & Mrs Purdie Bequests Scholarship and AstraZeneca for his PhD Studentship.
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