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dc.contributor.authorBailey, Christopher S.
dc.contributor.authorZarins-Tutt, Joseph S.
dc.contributor.authorAgbo, Matthias
dc.contributor.authorGao, Hong
dc.contributor.authorDiego-Taboada, Alberto
dc.contributor.authorGan, Maoluo
dc.contributor.authorHamed Farghal, Refaat B.
dc.contributor.authorAbraham, Emily
dc.contributor.authorMackenzie, Grahame
dc.contributor.authorEvans, P. Andrew
dc.contributor.authorGoss, Rebecca J. M.
dc.date.accessioned2019-07-03T11:30:07Z
dc.date.available2019-07-03T11:30:07Z
dc.date.issued2019-08-28
dc.identifier.citationBailey , C S , Zarins-Tutt , J S , Agbo , M , Gao , H , Diego-Taboada , A , Gan , M , Hamed Farghal , R B , Abraham , E , Mackenzie , G , Evans , P A & Goss , R J M 2019 , ' A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A ' , Chemical Science , vol. 10 , no. 32 , pp. 7549-7553 . https://doi.org/10.1039/C9SC01375Jen
dc.identifier.issn2041-6520
dc.identifier.otherPURE: 259131166
dc.identifier.otherPURE UUID: d138f9dd-d702-459f-bf43-e5f330eae59f
dc.identifier.otherScopus: 85070685197
dc.identifier.otherWOS: 000481422800004
dc.identifier.urihttp://hdl.handle.net/10023/18031
dc.descriptionThis work was supported by an MRC Case Studentship (JZT, RJMG), the European Research Council, funded under the European Union’s Seventh Framework Programme (FP7/2007-2013/ERC consolidator grant GCGXC grant agreement no 614779 to RJMG). We also gratefully acknowledge a CSC Scholarship (MG, RJMG), a BSAC Fellowship (MA, RJMG), and Sporomex Ltd (ADT) for supporting this work. NSERC is thanked for supporting a Tier 1 Canada Research Chair (PAE) and the Royal Society for a Wolfson Research Merit Award (PAE). We also thank W. Fenical (Scripps Institution of Oceanography, San Diego) for the kind provision of Marinispora strain CNQ-140.en
dc.description.abstractThe photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derived from the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularly short half-life in natural light, which severely impacts their potential biological utility given that they display potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin A dramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation by several orders of magnitude, thereby making this a potentially useful strategy for other light sensitive bioactive agents. In addition, we report that the SpECs can also be used to selectively extract culture broths that contain the marinomycins, which provides a significantly higher recovery than with conventional XAD resins and provides concomitant photoprotection.
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofChemical Scienceen
dc.rightsCopyright © 2019 The Authors. Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.en
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subjectBDCen
dc.subject.lccQDen
dc.titleA natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin Aen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1039/C9SC01375J
dc.description.statusPeer revieweden


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