St Andrews Research Repository

St Andrews University Home
View Item 
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A

Thumbnail
View/Open
Bailey_2019_CS_Naturalsolution_CC.pdf (989.0Kb)
Date
28/08/2019
Author
Bailey, Christopher S.
Zarins-Tutt, Joseph S.
Agbo, Matthias
Gao, Hong
Diego-Taboada, Alberto
Gan, Maoluo
Hamed Farghal, Refaat B.
Abraham, Emily
Mackenzie, Grahame
Evans, P. Andrew
Goss, Rebecca J. M.
Funder
European Research Council
Grant ID
GCGXC
Keywords
QD Chemistry
NDAS
BDC
Metadata
Show full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
Abstract
The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derived from the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularly short half-life in natural light, which severely impacts their potential biological utility given that they display potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin A dramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation by several orders of magnitude, thereby making this a potentially useful strategy for other light sensitive bioactive agents. In addition, we report that the SpECs can also be used to selectively extract culture broths that contain the marinomycins, which provides a significantly higher recovery than with conventional XAD resins and provides concomitant photoprotection.
Citation
Bailey , C S , Zarins-Tutt , J S , Agbo , M , Gao , H , Diego-Taboada , A , Gan , M , Hamed Farghal , R B , Abraham , E , Mackenzie , G , Evans , P A & Goss , R J M 2019 , ' A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A ' , Chemical Science , vol. 10 , no. 32 , pp. 7549-7553 . https://doi.org/10.1039/C9SC01375J
Publication
Chemical Science
Status
Peer reviewed
DOI
https://doi.org/10.1039/C9SC01375J
ISSN
2041-6520
Type
Journal article
Rights
Copyright © 2019 The Authors. Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Description
This work was supported by an MRC Case Studentship (JZT, RJMG), the European Research Council, funded under the European Union’s Seventh Framework Programme (FP7/2007-2013/ERC consolidator grant GCGXC grant agreement no 614779 to RJMG). We also gratefully acknowledge a CSC Scholarship (MG, RJMG), a BSAC Fellowship (MA, RJMG), and Sporomex Ltd (ADT) for supporting this work. NSERC is thanked for supporting a Tier 1 Canada Research Chair (PAE) and the Royal Society for a Wolfson Research Merit Award (PAE). We also thank W. Fenical (Scripps Institution of Oceanography, San Diego) for the kind provision of Marinispora strain CNQ-140.
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/18031

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Advanced Search

Browse

All of RepositoryCommunities & CollectionsBy Issue DateNamesTitlesSubjectsClassificationTypeFunderThis CollectionBy Issue DateNamesTitlesSubjectsClassificationTypeFunder

My Account

Login

Open Access

To find out how you can benefit from open access to research, see our library web pages and Open Access blog. For open access help contact: openaccess@st-andrews.ac.uk.

Accessibility

Read our Accessibility statement.

How to submit research papers

The full text of research papers can be submitted to the repository via Pure, the University's research information system. For help see our guide: How to deposit in Pure.

Electronic thesis deposit

Help with deposit.

Repository help

For repository help contact: Digital-Repository@st-andrews.ac.uk.

Give Feedback

Cookie policy

This site may use cookies. Please see Terms and Conditions.

Usage statistics

COUNTER-compliant statistics on downloads from the repository are available from the IRUS-UK Service. Contact us for information.

© University of St Andrews Library

University of St Andrews is a charity registered in Scotland, No SC013532.

  • Facebook
  • Twitter