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dc.contributor.authorYang, Ye
dc.contributor.authorPoss, Guillaume
dc.contributor.authorWeng, Yini
dc.contributor.authorQi, Runzhang
dc.contributor.authorZheng, Hanrui
dc.contributor.authorNianias, Nikolaos
dc.contributor.authorKay, Euan R.
dc.contributor.authorGuldin, Stefan
dc.identifier.citationYang , Y , Poss , G , Weng , Y , Qi , R , Zheng , H , Nianias , N , Kay , E R & Guldin , S 2019 , ' Probing the interaction of nanoparticles with small molecules in real time via quartz crystal microbalance monitoring ' , Nanoscale , vol. 11 , no. 23 , pp. 11107-11113 .
dc.identifier.otherBibtex: urn:f513cf2c85b7b18af2df9929413587c6
dc.identifier.otherORCID: /0000-0001-8177-6393/work/59222305
dc.descriptionY. Y. acknowledges University College London (UCL) for the Overseas Research Scholarship and the Graduate Research Scholarship. The project received funding from the European Unions Horizon 2020 research and innovation programme under grant agreement no. 633635 (DIACHEMO) and the EPSRC (grant number EP/J500549/1).en
dc.description.abstractDespite extensive advances in the field of molecular recognition, the real-time monitoring of small molecule binding to nanoparticles (NP) remains a challenge. To this end, we report on a versatile approach, based on quartz crystal microbalance with dissipation monitoring, for the stepwise in situ quantification of gold nanoparticle (AuNPs) immobilisation and subsequent uptake and release of binding partners. AuNPs stabilised by thiol-bound ligand shells of prescribed chemical composition were densely immobilised onto gold surfaces via dithiol linkers. The boronate ester formation between salicylic acid derivatives in solution and boronic acids in the AuNP ligand shell was then studied in real time, revealing a drastic effect of both ligand architecture and Lewis base concentration on the interaction strength. The binding kinetics were analysed with frequency response modelling for a thorough comparison of binding parameters including relaxation time as well as association rate constant. The results directly mirror those from previously reported in-depth studies using nuclear magnetic resonance spectroscopy. By achieving quantitative characterisation of selective binding of analytes with molecular weight below 300 Da, this new method enables rapid, low cost, rational screening of AuNP candidates for molecular recognition.
dc.subjectQD Chemistryen
dc.titleProbing the interaction of nanoparticles with small molecules in real time via quartz crystal microbalance monitoringen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.description.statusPeer revieweden

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