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Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae
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dc.contributor.author | Kohsaka, Hiroshi | |
dc.contributor.author | Zwart, Maarten F. | |
dc.contributor.author | Fushiki, Akira | |
dc.contributor.author | Fetter, Richard D. | |
dc.contributor.author | Truman, James W. | |
dc.contributor.author | Cardona, Albert | |
dc.contributor.author | Nose, Akinao | |
dc.date.accessioned | 2019-06-27T15:30:03Z | |
dc.date.available | 2019-06-27T15:30:03Z | |
dc.date.issued | 2019-06-14 | |
dc.identifier | 259396560 | |
dc.identifier | a3202141-04a4-4afa-8110-15a393a7ffbb | |
dc.identifier | 85067353917 | |
dc.identifier | 000471586800010 | |
dc.identifier.citation | Kohsaka , H , Zwart , M F , Fushiki , A , Fetter , R D , Truman , J W , Cardona , A & Nose , A 2019 , ' Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae ' , Nature Communications , vol. 10 , 2654 . https://doi.org/10.1038/s41467-019-10695-y | en |
dc.identifier.issn | 2041-1723 | |
dc.identifier.other | RIS: urn:C98DDEEF67864CD0E7ED7823213E3D2B | |
dc.identifier.other | RIS: Kohsaka2019 | |
dc.identifier.other | ORCID: /0000-0002-5073-8631/work/58984330 | |
dc.identifier.uri | https://hdl.handle.net/10023/17994 | |
dc.description | This work was supported by HHMI Janelia Visitor program (H.K. hosted by A.C.), the Howard Hughes Medical Institute (M.F.Z., A.F., R.D.F., J.W.T., and A.C.) and MEXT/JSPS KAKENHI grants (26430004 and 17K07042 to H.K., 221S0003, 22115002, 23300114, 15H04255, 17K19439, 17H05554, 18H05113, and 19H04742 to A.N.) | en |
dc.description.abstract | Animal locomotion requires spatiotemporally coordinated contraction of muscles throughout the body. Here, we investigate how contractions of antagonistic groups of muscles are intersegmentally coordinated during bidirectional crawling of Drosophila larvae. We identify two pairs of higher-order premotor excitatory interneurons present in each abdominal neuromere that intersegmentally provide feedback to the adjacent neuromere during motor propagation. The two feedback neuron pairs are differentially active during either forward or backward locomotion but commonly target a group of premotor interneurons that together provide excitatory inputs to transverse muscles and inhibitory inputs to the antagonistic longitudinal muscles. Inhibition of either feedback neuron pair compromises contraction of transverse muscles in a direction-specific manner. Our results suggest that the intersegmental feedback neurons coordinate contraction of synergistic muscles by acting as delay circuits representing the phase lag between segments. The identified circuit architecture also shows how bidirectional motor networks could be economically embedded in the nervous system. | |
dc.format.extent | 11 | |
dc.format.extent | 3953210 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nature Communications | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | QP Physiology | en |
dc.subject | NDAS | en |
dc.subject | BDC | en |
dc.subject.lcc | RC0321 | en |
dc.subject.lcc | QP | en |
dc.title | Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. Centre for Biophotonics | en |
dc.contributor.institution | University of St Andrews. School of Psychology and Neuroscience | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.identifier.doi | 10.1038/s41467-019-10695-y | |
dc.description.status | Peer reviewed | en |
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