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dc.contributor.authorKohsaka, Hiroshi
dc.contributor.authorZwart, Maarten F.
dc.contributor.authorFushiki, Akira
dc.contributor.authorFetter, Richard D.
dc.contributor.authorTruman, James W.
dc.contributor.authorCardona, Albert
dc.contributor.authorNose, Akinao
dc.identifier.citationKohsaka , H , Zwart , M F , Fushiki , A , Fetter , R D , Truman , J W , Cardona , A & Nose , A 2019 , ' Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae ' , Nature Communications , vol. 10 , 2654 .
dc.identifier.otherRIS: urn:C98DDEEF67864CD0E7ED7823213E3D2B
dc.identifier.otherRIS: Kohsaka2019
dc.identifier.otherORCID: /0000-0002-5073-8631/work/58984330
dc.descriptionThis work was supported by HHMI Janelia Visitor program (H.K. hosted by A.C.), the Howard Hughes Medical Institute (M.F.Z., A.F., R.D.F., J.W.T., and A.C.) and MEXT/JSPS KAKENHI grants (26430004 and 17K07042 to H.K., 221S0003, 22115002, 23300114, 15H04255, 17K19439, 17H05554, 18H05113, and 19H04742 to A.N.)en
dc.description.abstractAnimal locomotion requires spatiotemporally coordinated contraction of muscles throughout the body. Here, we investigate how contractions of antagonistic groups of muscles are intersegmentally coordinated during bidirectional crawling of Drosophila larvae. We identify two pairs of higher-order premotor excitatory interneurons present in each abdominal neuromere that intersegmentally provide feedback to the adjacent neuromere during motor propagation. The two feedback neuron pairs are differentially active during either forward or backward locomotion but commonly target a group of premotor interneurons that together provide excitatory inputs to transverse muscles and inhibitory inputs to the antagonistic longitudinal muscles. Inhibition of either feedback neuron pair compromises contraction of transverse muscles in a direction-specific manner. Our results suggest that the intersegmental feedback neurons coordinate contraction of synergistic muscles by acting as delay circuits representing the phase lag between segments. The identified circuit architecture also shows how bidirectional motor networks could be economically embedded in the nervous system.
dc.relation.ispartofNature Communicationsen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectQP Physiologyen
dc.titleRegulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvaeen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.description.statusPeer revieweden

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