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dc.contributor.authorKohsaka, Hiroshi
dc.contributor.authorZwart, Maarten F.
dc.contributor.authorFushiki, Akira
dc.contributor.authorFetter, Richard D.
dc.contributor.authorTruman, James W.
dc.contributor.authorCardona, Albert
dc.contributor.authorNose, Akinao
dc.date.accessioned2019-06-27T15:30:03Z
dc.date.available2019-06-27T15:30:03Z
dc.date.issued2019-06-14
dc.identifier.citationKohsaka , H , Zwart , M F , Fushiki , A , Fetter , R D , Truman , J W , Cardona , A & Nose , A 2019 , ' Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae ' , Nature Communications , vol. 10 , 2654 . https://doi.org/10.1038/s41467-019-10695-yen
dc.identifier.issn2041-1723
dc.identifier.otherPURE: 259396560
dc.identifier.otherPURE UUID: a3202141-04a4-4afa-8110-15a393a7ffbb
dc.identifier.otherRIS: urn:C98DDEEF67864CD0E7ED7823213E3D2B
dc.identifier.otherRIS: Kohsaka2019
dc.identifier.otherORCID: /0000-0002-5073-8631/work/58984330
dc.identifier.otherScopus: 85067353917
dc.identifier.otherWOS: 000471586800010
dc.identifier.urihttps://hdl.handle.net/10023/17994
dc.descriptionThis work was supported by HHMI Janelia Visitor program (H.K. hosted by A.C.), the Howard Hughes Medical Institute (M.F.Z., A.F., R.D.F., J.W.T., and A.C.) and MEXT/JSPS KAKENHI grants (26430004 and 17K07042 to H.K., 221S0003, 22115002, 23300114, 15H04255, 17K19439, 17H05554, 18H05113, and 19H04742 to A.N.)en
dc.description.abstractAnimal locomotion requires spatiotemporally coordinated contraction of muscles throughout the body. Here, we investigate how contractions of antagonistic groups of muscles are intersegmentally coordinated during bidirectional crawling of Drosophila larvae. We identify two pairs of higher-order premotor excitatory interneurons present in each abdominal neuromere that intersegmentally provide feedback to the adjacent neuromere during motor propagation. The two feedback neuron pairs are differentially active during either forward or backward locomotion but commonly target a group of premotor interneurons that together provide excitatory inputs to transverse muscles and inhibitory inputs to the antagonistic longitudinal muscles. Inhibition of either feedback neuron pair compromises contraction of transverse muscles in a direction-specific manner. Our results suggest that the intersegmental feedback neurons coordinate contraction of synergistic muscles by acting as delay circuits representing the phase lag between segments. The identified circuit architecture also shows how bidirectional motor networks could be economically embedded in the nervous system.
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.rightsCopyright © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectQP Physiologyen
dc.subjectNDASen
dc.subjectBDCen
dc.subject.lccRC0321en
dc.subject.lccQPen
dc.titleRegulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvaeen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.1038/s41467-019-10695-y
dc.description.statusPeer revieweden


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