Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae
Date
14/06/2019Author
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Abstract
Animal locomotion requires spatiotemporally coordinated contraction of muscles throughout the body. Here, we investigate how contractions of antagonistic groups of muscles are intersegmentally coordinated during bidirectional crawling of Drosophila larvae. We identify two pairs of higher-order premotor excitatory interneurons present in each abdominal neuromere that intersegmentally provide feedback to the adjacent neuromere during motor propagation. The two feedback neuron pairs are differentially active during either forward or backward locomotion but commonly target a group of premotor interneurons that together provide excitatory inputs to transverse muscles and inhibitory inputs to the antagonistic longitudinal muscles. Inhibition of either feedback neuron pair compromises contraction of transverse muscles in a direction-specific manner. Our results suggest that the intersegmental feedback neurons coordinate contraction of synergistic muscles by acting as delay circuits representing the phase lag between segments. The identified circuit architecture also shows how bidirectional motor networks could be economically embedded in the nervous system.
Citation
Kohsaka , H , Zwart , M F , Fushiki , A , Fetter , R D , Truman , J W , Cardona , A & Nose , A 2019 , ' Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae ' , Nature Communications , vol. 10 , 2654 . https://doi.org/10.1038/s41467-019-10695-y
Publication
Nature Communications
Status
Peer reviewed
ISSN
2041-1723Type
Journal article
Rights
Copyright © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Description
This work was supported by HHMI Janelia Visitor program (H.K. hosted by A.C.), the Howard Hughes Medical Institute (M.F.Z., A.F., R.D.F., J.W.T., and A.C.) and MEXT/JSPS KAKENHI grants (26430004 and 17K07042 to H.K., 221S0003, 22115002, 23300114, 15H04255, 17K19439, 17H05554, 18H05113, and 19H04742 to A.N.)Collections
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