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dc.contributor.authorBarnard, Isla Rose Mary
dc.contributor.authorTierney, Patrick
dc.contributor.authorCampbell, Catherine Louise
dc.contributor.authorMcMillan, Lewis
dc.contributor.authorMoseley, Harry
dc.contributor.authorEadie, Ewan
dc.contributor.authorBrown, Christian Thomas Alcuin
dc.contributor.authorWood, Kenneth
dc.date.accessioned2019-06-25T23:41:17Z
dc.date.available2019-06-25T23:41:17Z
dc.date.issued2018-09
dc.identifier.citationBarnard , I R M , Tierney , P , Campbell , C L , McMillan , L , Moseley , H , Eadie , E , Brown , C T A & Wood , K 2018 , ' Quantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbeds ' , Photochemistry and Photobiology , vol. 94 , no. 5 , pp. 1017-1025 . https://doi.org/10.1111/php.12935en
dc.identifier.issn0031-8655
dc.identifier.otherPURE: 252065900
dc.identifier.otherPURE UUID: f06ed161-421c-45ab-8c92-6ea3f9c04708
dc.identifier.otherScopus: 85053265648
dc.identifier.otherORCID: /0000-0002-7725-5162/work/58531632
dc.identifier.otherWOS: 000444423500021
dc.identifier.urihttp://hdl.handle.net/10023/17961
dc.descriptionFunding: UK EPRSC PhD studentship number EP/N509759/1.en
dc.description.abstractNonmelanoma and melanoma skin cancers are attributable to DNA damage caused by ultraviolet (UV) radiation exposure. One DNA photoproduct, the Cyclobutane Pyrimidine Dimer (CPD), is believed to lead to DNA mutations caused by UV radiation. Using radiative transfer simulations, we compare the number of CPDs directly induced by UV irradiation from artificial and natural UV sources (a standard sunbed and the midday summer Mediterranean sun) for skin types I and II on the Fitzpatrick scale. We use Monte Carlo Radiative Transfer (MCRT) modelling to track the progression of UV photons through a multilayered three dimensional (3D) grid that simulates the upper layers of the skin. By recording the energy deposited in the DNA-containing cells of the basal layer, the number of CPDs formed can be quantified. The aim of this work was to compare the number of CPDs formed in the basal layer of the skin, and by implication the risk of developing cancer, as a consequence of irradiation by artificial and natural sources. Our simulations show that the number of CPDs formed per second during sunbed irradiation is almost three times that formed during solar irradiation.
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofPhotochemistry and Photobiologyen
dc.rights© 2018 The American Society of Photobiology. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1111/php.12935en
dc.subjectUVen
dc.subjectUVAen
dc.subjectDNA Damageen
dc.subjectQC Physicsen
dc.subjectQD Chemistryen
dc.subjectQH301 Biologyen
dc.subjectRL Dermatologyen
dc.subjectDASen
dc.subject.lccQCen
dc.subject.lccQDen
dc.subject.lccQH301en
dc.subject.lccRLen
dc.titleQuantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbedsen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.identifier.doihttps://doi.org/10.1111/php.12935
dc.description.statusPeer revieweden
dc.date.embargoedUntil2019-06-26


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