Quantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbeds
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Nonmelanoma and melanoma skin cancers are attributable to DNA damage caused by ultraviolet (UV) radiation exposure. One DNA photoproduct, the Cyclobutane Pyrimidine Dimer (CPD), is believed to lead to DNA mutations caused by UV radiation. Using radiative transfer simulations, we compare the number of CPDs directly induced by UV irradiation from artificial and natural UV sources (a standard sunbed and the midday summer Mediterranean sun) for skin types I and II on the Fitzpatrick scale. We use Monte Carlo Radiative Transfer (MCRT) modelling to track the progression of UV photons through a multilayered three dimensional (3D) grid that simulates the upper layers of the skin. By recording the energy deposited in the DNA-containing cells of the basal layer, the number of CPDs formed can be quantified. The aim of this work was to compare the number of CPDs formed in the basal layer of the skin, and by implication the risk of developing cancer, as a consequence of irradiation by artificial and natural sources. Our simulations show that the number of CPDs formed per second during sunbed irradiation is almost three times that formed during solar irradiation.
Barnard , I R M , Tierney , P , Campbell , C L , McMillan , L , Moseley , H , Eadie , E , Brown , C T A & Wood , K 2018 , ' Quantifying direct DNA damage in the basal layer of skin exposed to UV radiation from sunbeds ' , Photochemistry and Photobiology , vol. 94 , no. 5 , pp. 1017-1025 . https://doi.org/10.1111/php.12935
Photochemistry and Photobiology
© 2018 The American Society of Photobiology. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1111/php.12935
DescriptionFunding: UK EPRSC PhD studentship number EP/N509759/1.
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