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Approaches to CNS drug delivery with a focus on transporter-mediated transcytosis
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dc.contributor.author | Abdul Razzak, Rana | |
dc.contributor.author | Florence, Gordon John | |
dc.contributor.author | Gunn-Moore, Francis James | |
dc.date.accessioned | 2019-06-25T14:30:06Z | |
dc.date.available | 2019-06-25T14:30:06Z | |
dc.date.issued | 2019-06-25 | |
dc.identifier | 259340916 | |
dc.identifier | 7dae642f-d836-47d3-81a2-db44acf43fa3 | |
dc.identifier | 000473756000258 | |
dc.identifier | 85068897518 | |
dc.identifier.citation | Abdul Razzak , R , Florence , G J & Gunn-Moore , F J 2019 , ' Approaches to CNS drug delivery with a focus on transporter-mediated transcytosis ' , International Journal of Molecular Sciences , vol. 20 , no. 12 , 3108 . https://doi.org/10.3390/ijms20123108 | en |
dc.identifier.issn | 1422-0067 | |
dc.identifier.other | ORCID: /0000-0003-3422-3387/work/58984291 | |
dc.identifier.other | ORCID: /0000-0001-9921-4399/work/58984313 | |
dc.identifier.uri | https://hdl.handle.net/10023/17958 | |
dc.description | Funding: Alzheimer’s Scotland, Alzheimer’s Society, Rosetrees Trust and RS MacDonald Charitable Trust. | en |
dc.description.abstract | Drug delivery to the central nervous system (CNS) conferred by brain barriers is a major obstacle in the development of effective neurotherapeutics. In this review, a classification of current approaches of clinical or investigational importance for the delivery of therapeutics to the CNS is presented. This classification includes the use of formulations administered systemically that can elicit transcytosis-mediated transport by interacting with transporters expressed by transvascular endothelial cells. Neurotherapeutics can also be delivered to the CNS by means of surgical intervention using specialized catheters or implantable reservoirs. Strategies for delivering drugs to the CNS have evolved tremendously during the last two decades, yet, some factors can affect the quality of data generated in preclinical investigation, which can hamper the extension of the applications of these strategies into clinically useful tools. Here, we disclose some of these factors and propose some solutions that may prove valuable at bridging the gap between preclinical findings and clinical trials. | |
dc.format.extent | 43 | |
dc.format.extent | 11902414 | |
dc.language.iso | eng | |
dc.relation.ispartof | International Journal of Molecular Sciences | en |
dc.subject | CNS-targeted drug delivery | en |
dc.subject | Blood-brain barrier | en |
dc.subject | Receptor-mediated transcytosis | en |
dc.subject | Transient BBB disruption | en |
dc.subject | Efflux-pump inhibition | en |
dc.subject | Ring-opening metathesis polymerization | en |
dc.subject | QD Chemistry | en |
dc.subject | RM Therapeutics. Pharmacology | en |
dc.subject | T-NDAS | en |
dc.subject.lcc | QD | en |
dc.subject.lcc | RM | en |
dc.title | Approaches to CNS drug delivery with a focus on transporter-mediated transcytosis | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis | en |
dc.contributor.institution | University of St Andrews. Centre for Biophotonics | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.identifier.doi | 10.3390/ijms20123108 | |
dc.description.status | Peer reviewed | en |
dc.identifier.url | https://www.mdpi.com/1422-0067/20/12/3108 | en |
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