Approaches to CNS drug delivery with a focus on transporter-mediated transcytosis
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Drug delivery to the central nervous system (CNS) conferred by brain barriers is a major obstacle in the development of effective neurotherapeutics. In this review, a classification of current approaches of clinical or investigational importance for the delivery of therapeutics to the CNS is presented. This classification includes the use of formulations administered systemically that can elicit transcytosis-mediated transport by interacting with transporters expressed by transvascular endothelial cells. Neurotherapeutics can also be delivered to the CNS by means of surgical intervention using specialized catheters or implantable reservoirs. Strategies for delivering drugs to the CNS have evolved tremendously during the last two decades, yet, some factors can affect the quality of data generated in preclinical investigation, which can hamper the extension of the applications of these strategies into clinically useful tools. Here, we disclose some of these factors and propose some solutions that may prove valuable at bridging the gap between preclinical findings and clinical trials.
Abdul Razzak , R , Florence , G J & Gunn-Moore , F J 2019 , ' Approaches to CNS drug delivery with a focus on transporter-mediated transcytosis ' , International Journal of Molecular Sciences , vol. 20 , no. 12 , 3108 . https://doi.org/10.3390/ijms20123108
International Journal of Molecular Sciences
©2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DescriptionFunding: Alzheimer’s Scotland, Alzheimer’s Society, Rosetrees Trust and RS MacDonald Charitable Trust.
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