Modelling cell-cell collision and adhesion with the Filament Based Lamellipodium Model
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We extend the live-cell motility Filament Based Lamellipodium Model to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new components have in the migration and morphology of the cells through particular experiments. We exhibit moreover the similarities between our simulated cells and HeLa cancer cells.
Sfakianakis , N , Peurichard , D , Brunk , A & Schmeiser , C 2018 , ' Modelling cell-cell collision and adhesion with the Filament Based Lamellipodium Model ' , BIOMATH , vol. 7 , no. 2 , 1811097 . https://doi.org/10.11145/j.biomath.2018.11.097
Copyright 2018 Sfakianakis et al. This article is distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DescriptionFunding: N.S was partially supported by the German Science Foundation (DFG) under the grant SFB 873 “Maintenance and Differentiation of Stem Cells in Development and Disease”.
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