Best practice considerations for using the selectivity factor, s, as a metric for the efficiency of kinetic resolutions
Abstract
The suitability of using the selectivity factor, s, as a reaction metric for kinetic resolution reactions and the errors associated with its measurement are considered. Investigation of the analytical error associated with HPLC analysis of a kinetic resolution reveals that one of the largest potential sources of variation arises from the ability of a practitioner to integrate the peaks from a single analysis. The consequences of this error on the reliability of reported s values are discussed, and some general rules for good practice regarding the use and reporting of s as a metric are suggested.
Citation
Greenhalgh , M D , Taylor , J E & Smith , A D 2018 , ' Best practice considerations for using the selectivity factor, s , as a metric for the efficiency of kinetic resolutions ' , Tetrahedron , vol. 74 , no. 38 , pp. 5554-5560 . https://doi.org/10.1016/j.tet.2018.05.069
Publication
Tetrahedron
Status
Peer reviewed
ISSN
0040-4020Type
Journal article
Description
The research leading to these results has received funding from the ERC under the European Union’s Seventh Framework Programme (FP7/2007--2013)/E.R.C. grant agreement 279850. J.E.T. thanks The Leverhulme Trust [Early Career Fellowship ECF-2014-005] for financial support. A.D.S. thanks the Royal Society for a Wolfson Merit Award.Collections
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.