Best practice considerations for using the selectivity factor, s, as a metric for the efficiency of kinetic resolutions
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The suitability of using the selectivity factor, s, as a reaction metric for kinetic resolution reactions and the errors associated with its measurement are considered. Investigation of the analytical error associated with HPLC analysis of a kinetic resolution reveals that one of the largest potential sources of variation arises from the ability of a practitioner to integrate the peaks from a single analysis. The consequences of this error on the reliability of reported s values are discussed, and some general rules for good practice regarding the use and reporting of s as a metric are suggested.
Greenhalgh , M D , Taylor , J E & Smith , A D 2018 , ' Best practice considerations for using the selectivity factor, s , as a metric for the efficiency of kinetic resolutions ' , Tetrahedron , vol. 74 , no. 38 , pp. 5554-5560 . https://doi.org/10.1016/j.tet.2018.05.069
Crown Copyright © 2018 Published by Elsevier Ltd. All rights reserved. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.tet.2018.05.069
DescriptionThe research leading to these results has received funding from the ERC under the European Union’s Seventh Framework Programme (FP7/2007--2013)/E.R.C. grant agreement 279850. J.E.T. thanks The Leverhulme Trust [Early Career Fellowship ECF-2014-005] for financial support. A.D.S. thanks the Royal Society for a Wolfson Merit Award.
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