Molecular aspects of the activity and inhibition of the FAD-containing monoamine oxidases
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1. Introduction 2. FAD: the catalytic cofactor 2.1 FAD is covalently attached to MAO 2.3 FAD is modified by irreversible inhibitors 3. MAO proteins 3.1 MAO protein expression and turnover 3.2 MAO A and MAO B structures and active sites 3.3 MAO chemical mechanism 3.4 MAO kinetic mechanism: two-substrate kinetics 4. Substrate Specificity of these Promiscuous Enzymes 4.1 Neurotransmitter metabolism 4.2 Metabolism of biogenic amines 4.3 Products from MAO catalysis 5. Inhibition of MAO 5.1 Reversible inhibitors of MAO 5.2 Examples of tight binding reversible inhibitors of MAO 5.3 Examples of irreversible inhibitors of MAO 6. Computational innovation 6.1 Theoretical elucidation of mechanism 6.2 Data-mining and tools for drug discovery 7. Conclusion: the future for MAO inhibition in multi-target drugs
Ramsay , R R 2019 , Molecular aspects of the activity and inhibition of the FAD-containing monoamine oxidases . in P Grunwald (ed.) , Pharmaceutical Biocatalysis : Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases . vol. 4 , Series on Biocatalysis , no. 10 , vol. 4 , Pan Stanford Publishing Pte. Ltd. , Singapore .
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