Molecular aspects of the activity and inhibition of the FAD-containing monoamine oxidases

Abstract

1. Introduction 2. FAD: the catalytic cofactor 2.1 FAD is covalently attached to MAO 2.3 FAD is modified by irreversible inhibitors 3. MAO proteins 3.1 MAO protein expression and turnover 3.2 MAO A and MAO B structures and active sites 3.3 MAO chemical mechanism 3.4 MAO kinetic mechanism: two-substrate kinetics 4. Substrate Specificity of these Promiscuous Enzymes 4.1 Neurotransmitter metabolism 4.2 Metabolism of biogenic amines 4.3 Products from MAO catalysis 5. Inhibition of MAO 5.1 Reversible inhibitors of MAO 5.2 Examples of tight binding reversible inhibitors of MAO 5.3 Examples of irreversible inhibitors of MAO 6. Computational innovation 6.1 Theoretical elucidation of mechanism 6.2 Data-mining and tools for drug discovery 7. Conclusion: the future for MAO inhibition in multi-target drugs