Manganese catalyzed hydrogenation of enantiomerically pure esters
Abstract
A manganese-catalyzed hydrogenation of esters has been accomplished with TON up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.
Citation
Widegren , M B & Clarke , M L 2018 , ' Manganese catalyzed hydrogenation of enantiomerically pure esters ' , Organic Letters , vol. 20 , no. 9 , pp. 2654-2658 . https://doi.org/10.1021/acs.orglett.8b00864
Publication
Organic Letters
Status
Peer reviewed
ISSN
1523-7060Type
Journal article
Rights
Copyright © 2018 American Chemical Society. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1021/acs.orglett.8b00864
Description
The authors thank the EPSRC for DTG funding for MBW. The technical support staff at St Andrews are also gratefully acknowledged. The research data supporting this publication can be accessed at: dx.doi.org/10.17630/29308cf7-b6b6- 4b1b-809b-a12fe91b250fCollections
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