Biomedical Sciences Research Complex (BSRC): Recent submissions

Now showing items 26-30 of 43

    • Structural and functional characterisation of Mcb1 and the MCMᴹᶜᵇ¹ complex in Schizosaccharomyces pombe 

      Schnick, Jasmin (University of St Andrews, 2014-06) - Thesis
      The MCM helicase plays an important role in eukaryotic DNA replication, unwinding double stranded DNA ahead of the replication fork. MCM is a hetero-hexamer consisting of the six related proteins, Mcm2-Mcm7. The distantly ...

    • Human tissue in systems medicine 

      Caie, Peter David; Schuur, Klaas; Oniscu, Anca; Mullen, Peter; Reynolds, Paul Andrew; Harrison, David James (2013-12) - Journal item
      Histopathology, the examination of an architecturally artefactual, two dimensional, static image remains a potent tool allowing diagnosis and empirical expectation of prognosis. Considerable optimism exists that the advent ...

    • Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe Ç 

      Edwards, Thomas E.; Cekan, Pavol; Reginsson, Gunnar Widtfeldt; Shelke, Sandip A.; Ferre D'Amare, Adrian R.; Schiemann, Olav; Sigurdsson, Snorri (2011-05) - Journal article
      Electron Paramagnetic Resonance (EPR) spectroscopy and fluorescence spectroscopy are complementary biophysical techniques used to examine the structure and dynamics of macromolecules. We have previously described the ...

    • Femtosecond optoinjection of intact tobacco BY-2 cells using a reconfigurable photoporation platform 

      Mitchell, C.A.; Kalies, S.; Cizmár, T.; Heisterkamp, A.; Torrance, L.; Roberts, A.G.; Gunn-Moore, F.J.; Dholakia, K. (2013-11-14) - Journal article
      A tightly-focused ultrashort pulsed laser beam incident upon a cell membrane has previously been shown to transiently increase cell membrane permeability while maintaining the viability of the cell, a technique known as ...

    • Structural studies of CRISPR-associated proteins 

      Reeks, Judith (University of St Andrews, 2013-11-29) - Thesis
      Clustered regularly interspaced short palindromic repeats (CRISPRs) act to prevent viral infection and horizontal gene transfer in prokaryotes. The genomic CRISPR array contains short sequences (“spacers”) that are derived ...