The Biomedical Sciences Research Complex (BSRC) is an interdisciplinary research centre involving the Schools of Biology, Chemistry, Medicine and Physics and Astronomy. Research at the centre focuses on infection and immunity, chemical biology, DNA repair and enzymology, and is underpinned by world-class facilities for structural biology, proteomics and synthetic chemistry.

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  • Isothiourea-catalyzed enantioselective addition of 4-nitrophenyl esters to iminium ions 

    Arokianathar, Jude N.; Frost, Aileen B.; Slawin, Alexandra M. Z.; Stead, Darren; Smith, Andrew D. (2018-02-02) - Journal article
    Isothioureas catalyze the enantioselective addition of 4-nitrophenyl esters to tetrahydroisoquinoline-derived iminium ions. 4-Nitrophenoxide, generated in situ from initial N-acylation of the isothiourea by the 4-nitrophenyl ...
  • A new method for post-translationally labeling proteins in live cells for fluorescence imaging and tracking 

    Hinrichsen, M.; Lenz, M.; Edwards, J. M.; Miller, O. K.; Mochrie, S. G. J.; Swain, P. S.; Schwarz-Linek, U.; Regan, L. (2017-12) - Journal article
    We present a novel method to fluorescently label proteins, post-translationally, within live Saccharomycescerevisiae. The premise underlying this work is that fluorescent protein (FP) tags are less disruptive to normal ...
  • Direct and indirect approaches to identify drug modes of action 

    Tulloch, Lindsay B.; Menzies, Stefanie K.; Coron, Ross P.; Roberts, Matthew D.; Florence, Gordon J.; Smith, Terry K. (2018-01) - Journal item
    Phenotypic assays are becoming increasingly more common among drug discovery practices, expanding drug target diversity as lead compounds identified through such screens are not limited to known targets. While increasing ...
  • The evolution of ependymin-related proteins 

    McDougall, Carmel; Hammond, Michael; Dailey, Simon C.; Somorjai, Ildiko M. L.; Cummins, Scott; Degnan, Bernard (2018-12-04) - Journal article
    Background: Ependymins were originally defined as fish-specific secreted glycoproteins involved in central nervous system plasticity and memory formation. Subsequent research revealed that these proteins represent a ...
  • Synthesis of the natural product descurainolide and cyclic peptides from lignin-derived aromatics 

    Ojo, O. Stephen; Nardone, Brunello; Musolino, Stefania Francesca; Neal, Andrew; Wilson, Liam; Lebl, Tomas; Slawin, Alexandra Martha Zoya; Cordes, David Bradford; Taylor, James Edward; Naismith, James H.; Smith, Andrew D.; Westwood, Nicholas J. (2018-01-14) - Journal article
    Alternative sources of potential feedstock chemicals are of increasing importance as the availability of oil decreases. The biopolymer lignin is viewed as a source of useful mono-aromatic compounds as exemplified by the ...

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