Biomedical Sciences Research Complex (BSRC)
The Biomedical Sciences Research Complex (BSRC) is an interdisciplinary research centre involving the Schools of Biology, Chemistry, Medicine and Physics and Astronomy. Research at the centre focuses on infection and immunity, chemical biology, DNA repair and enzymology, and is underpinned by world-class facilities for structural biology, proteomics and synthetic chemistry.
For more information please visit the Biomedical Sciences Research Complex (BSRC) home page.
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In vitro assay development and HTS of small molecule human ABAD/17β-HSD10 inhibitors as therapeutics in Alzheimer’s Disease (2017-03-17) - Journal articleA major hallmark of Alzheimer’s disease (AD) is the formation of neurotoxic aggregates composed of the amyloid-β peptide (Aβ). Aβ has been recognized to interact with numerous proteins, resulting in pathological changes ...
(2017-02-06) - Journal articleWith lignin-first biorefineries likely to become a reality, controlled depolymerization of high-quality lignin streams to high value products has become a priority. Using bisulfite chemistry, access to a high-β-O-4 content ...
Diphosphane 2,2′-binaphtho[1,8-de][1,3,2]dithiaphosphinine and the easy formation of a stable phosphorus radical cation (2016-04-21) - Journal articleA convenient synthesis route to 2,2’-binaphtho[1,8-de][1,3,2]di-thiaphosphinine (3) was found. Its stable radical cation 3•+ was accessed easily through one-electron oxidation with NOBF4.
(2016-04-14) - Journal articleThe all-cis isomer of 1,2,3,4-tetrafluorocyclopentane is prepared and characterised by NMR and X-ray crystallography and the experimental structure compared with theory. The structure has a similarly high polarity to all-cis ...
Structure and cardioprotective activities of polar lipids of olive pomace, olive pomace-enriched fish feed and olive pomace fed gilthead sea bream (Sparus aurata) (2016-05) - Journal articleTotal lipids of olive pomace (OP), olive pomace diet (OP diet), fish oil diet (FO diet) and fish filets of farmed gilthead sea bream (fish fed with FO diet and OP diet respectively) were extracted and separated into polar ...