The Biomedical Sciences Research Complex (BSRC) is an interdisciplinary research centre involving the Schools of Biology, Chemistry, Medicine and Physics and Astronomy. Research at the centre focuses on infection and immunity, chemical biology, DNA repair and enzymology, and is underpinned by world-class facilities for structural biology, proteomics and synthetic chemistry.

For more information please visit the Biomedical Sciences Research Complex (BSRC) home page.

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  • Human cytomegalovirus immediate early 1 protein causes loss of SOX2 from neural progenitor cells by trapping unphosphorylated STAT3 in the nucleus 

    Wu, Cong-Cong; Jiang, Xuan; Wang, Xian-Zhang; Liu, Xi-Juan; Li, Xiao-Jun; Yang, Bo; Ye, Han-Qing; Harwardt, Thomas; Jiang, Man; Xia, Hui-Min; Wang, Wei; Britt, William J.; Paulus, Christina; Nevels, Michael Martin; Luo, Min-Hua (2018-09) - Journal article
    The mechanisms underlying neurodevelopmental damage caused by virus infections remain poorly defined. Congenital human cytomegalovirus (HCMV) infection is the leading cause of fetal brain development disorders. Previous ...
  • Heat-inactivation renders sputum safe and preserves Mycobacterium tuberculosis RNA for downstream molecular tests 

    Sabiiti, Wilber; Azam, Khalide; Esmeraldo, Ezembro; Bhatt, Nilesh; Rachow, Andrea; Gillespie, Stephen H. (2019-02-06) - Journal article
    The World Health Organization End tuberculosis (TB) strategy has called for development of- and increased access to- effective tools for diagnosis and treatment of TB disease. Mycobacterium tuberculosis (Mtb), the causative ...
  • Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia 

    Gialluisi, Alessandro; Andlauer, Till F. M.; Mirza-schreiber, Nazanin; Moll, Kristina; Becker, Jessica; Hoffmann, Per; Ludwig, Kerstin U.; Czamara, Darina; St Pourcain, Beate; Brandler, William; Honbolygó, Ferenc; Tóth, Dénes; Csépe, Valéria; Huguet, Guillaume; Morris, Andrew P.; Hulslander, Jacqueline; Willcutt, Erik G.; Defries, John C.; Olson, Richard K.; Smith, Shelley D.; Pennington, Bruce F.; Vaessen, Anniek; Maurer, Urs; Lyytinen, Heikki; Peyrard-janvid, Myriam; Leppänen, Paavo H. T.; Brandeis, Daniel; Bonte, Milene; Stein, John F.; Talcott, Joel B.; Fauchereau, Fabien; Wilcke, Arndt; Francks, Clyde; Bourgeron, Thomas; Monaco, Anthony P.; Ramus, Franck; Landerl, Karin; Kere, Juha; Scerri, Thomas S.; Paracchini, Silvia; Fisher, Simon E.; Schumacher, Johannes; Nöthen, Markus M.; Müller-myhsok, Bertram; Schulte-körne, Gerd (2019-02-11) - Journal article
    Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), ...
  • Light sheet microscopy with acoustic sample confinement 

    Yang, Zhengyi; Cole, Katy L.H.; Qiu, Yongqiang; Somorjai, Ildiko Maureen Lara; Wijesinghe, Philip; Nylk, Jonathan; Cochran, Sandy; Spalding, Gabriel C.; Lyons, David A.; Dholakia, Kishan (2019-02-08) - Journal article
    Contactless sample confinement would enable a whole host of new studies in developmental biology and neuroscience, in particular, when combined with long-term, wide-field optical imaging. To achieve this goal, we demonstrate ...
  • Translational biology of nematode effectors. Or, to put it another way, functional analysis of effectors – what’s the point? 

    Mantelin, Sophie; Thorpe, Peter; Jones, John T. (2017) - Journal article
    There has been a huge amount of work put into identifying and characterising effectors from plant-parasitic nematodes in recent years. Although this work has provided insights into the mechanisms by which nematodes can ...

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