The Biomedical Sciences Research Complex (BSRC) is an interdisciplinary research centre involving the Schools of Biology, Chemistry, Medicine and Physics and Astronomy. Research at the centre focuses on infection and immunity, chemical biology, DNA repair and enzymology, and is underpinned by world-class facilities for structural biology, proteomics and synthetic chemistry.

For more information please visit the Biomedical Sciences Research Complex (BSRC) home page.

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  • Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain 

    Albuixech-Crespo, Beatriz; López-Blanch, Laura; Burguera, Demian; Maeso, Ignacio; Sánchez Arrones, Luisa; Moreno-Bravo, Juan Antonio; Somorjai, Ildiko; Pascual-Anaya, Juan; Puelles, Eduardo; Bovolenta, Paola; Garcia-Fernàndez, Jordi; Puelles, Luis; Irimia, Manuel; Ferran, José Luis (2017-04-19) - Journal article
    All vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still ...
  • Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells 

    Tilston-Lunel, Andrew Martin; Haley, Kathryn; Schlecht, Nicolas; Wang, Yanhua; Chatterton, Abigail Louise Dougal; Moleirinho, Susana Luisa; Watson, Ailsa; Hundal, Harinder; Prystowsky, Michael; Gunn-Moore, Francis James; Reynolds, Paul Andrew (2016-10) - Journal article
    Crumbs3 (CRB3) is a component of epithelial junctions that has been implicated in apical-basal polarity, apical identity, apical stability, cell adhesion and cell growth. CRB3 undergoes alternative splicing to yield two ...
  • Rapid evolution and gene expression : a rapidly-evolving Mendelian trait that silences field crickets has widespread effects on mRNA and protein expression 

    Pascoal, Sonia Christina Marques; Liu, Xuan; Ly, Tony; Fang, Yongxiang; Rockliffe, Nichola; Paterson, Steve; Shirran, Sally Lorna; Botting, Catherine Helen; Bailey, Nathan William (2016-06) - Journal article
    A major advance in modern evolutionary biology is the ability to start linking phenotypic evolution in the wild with genomic changes that underlie that evolution. We capitalised on a rapidly-evolving Hawaiian population ...
  • Kinetic landscape of a peptide-bond-forming prolyl oligopeptidase 

    Czekster, Clarissa M.; Naismith, James H. (2017-04-18) - Journal article
    Prolyl oligopeptidase B from Galerina marginata (GmPOPB) has recently been discovered as a peptidase capable of breaking and forming peptide bonds to yield a cyclic peptide. Despite the relevance of prolyl oligopeptidases ...
  • Within host RNA virus persistence : mechanisms and consequences 

    Randall, Richard E.; Griffin, Diane E. (2017-04) - Journal item
    In a prototypical response to an acute viral infection it would be expected that the adaptive immune response would eliminate all virally infected cells within a few weeks of infection. However many (non-retrovirus) RNA ...

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