The Biomedical Sciences Research Complex (BSRC) is an interdisciplinary research centre involving the Schools of Biology, Chemistry, Medicine and Physics and Astronomy. Research at the centre focuses on infection and immunity, chemical biology, DNA repair and enzymology, and is underpinned by world-class facilities for structural biology, proteomics and synthetic chemistry.

For more information please visit the Biomedical Sciences Research Complex (BSRC) home page.

Recent Submissions

  • Moxifloxacin replacement in contemporary tuberculosis drug regimens is ineffective against persistent Mycobacterium tuberculosis : in the Cornell mouse model 

    Liu, Yingjun; Pertinez, Henry; Davies, Geraint R; Gillespie, Stephen H; Coates, Anthony R; Hu, Yanmin (2018-07) - Journal article
    Tuberculosis (TB), which is caused by Mycobacterium tuberculosis, remains a leading killer worldwide, and disease control is hampered by the ineffective control of persistent infections. Substitution of moxifloxacin for ...
  • Wide-field multiphoton imaging through scattering media without correction 

    Escobet-Montalbán, Adrià; Spesyvtsev, Roman; Chen, Mingzhou; Saber, Wardiya Afshar; Andrews, Melissa; Herrington, C. Simon; Mazilu, Michael; Dholakia, Kishan (2018-10-12) - Journal article
    Optical approaches to fluorescent, spectroscopic and morphological imaging have made exceptional advances in the last decade. Super-resolution imaging and wide-field multiphoton imaging are now underpinning major advances ...
  • Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC 

    Harrison, Ewan M.; Paterson, Gavin K.; Holden, Matthew Thomas Geoffrey; Larsen, Jesper; Stegger, Marc; Larsen, Anders Rhod; Petersen, Andreas; Skov, Robert L.; Christensen, Judit Marta; Zeuthen, Anne Bak; Heltberg, Ole; Harris, Simon R.; Zadoks, Ruth N.; Parkhill, Julian; Peacock, Sharon J.; Holmes, Mark A. (2013-04) - Journal article
    Several methicillin-resistant Staphylococcus aureus (MRSA) lineages that carry a novel mecA homologue (mecC) have recently been described in livestock and humans. In Denmark, two independent human cases of mecC-MRSA infection ...
  • Metabolic inhibitors of O-GlcNAc transferase (OGT) that act in vivo implicate decreased O-GlcNAc levels in leptin-mediated nutrient sensing 

    Liu, Ta-wei; Zandberg, Wesley F.; Gloster, Tracey M.; Deng, Lehua; Murray, Kelsey D; Shan, Xiaoyang; Vocadlo, David Jaro (2018-06-25) - Journal article
    O‐linked glycosylation of serine and threonine residues of nucleocytoplasmic proteins with N‐acetylglucosamine (O‐GlcNAc) residues is catalyzed by O‐GlcNAc transferase (OGT). O‐GlcNAc is conserved within mammals and is ...
  • Phenotypic changes on Mycobacterium tuberculosis-specific CD4 T cells as surrogate markers for tuberculosis treatment efficacy 

    Ahmed, Mohamed I. M.; Ntinginya, Nyanda E.; Kibiki, Gibson; Mtafya, Bariki A; Semvua, Hadija; Mpagama, Stellah; Mtabho, Charles; Saathoff, Elmar; Held, Kathrin; Loose, Rebecca; Kroidl, Inge; Chachage, Mkunde; Both, Ulrich von; Haule, Antelmo; Mekota, Anna-Maria; Boeree, Martin J.; Gillespie, Stephen H.; Hoelscher, Michael; Heinrich, Norbert; Geldmacher, Christof; Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA) (2018-09-28) - Journal article
    Background: The analysis of phenotypic characteristics on Mycobacterium tuberculosis (MTB)-specific T cells is a promising approach for the diagnosis of active tuberculosis (aTB) and for monitoring treatment success. We ...

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