Biomedical Sciences Research Complex (BSRC) Research
The Biomedical Sciences Research Complex (BSRC) is an interdisciplinary research centre involving the Schools of Biology, Chemistry, Medicine and Physics and Astronomy. Research at the centre focuses on infection and immunity, chemical biology, DNA repair and enzymology, and is underpinned by world-class facilities for structural biology, proteomics and synthetic chemistry.
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(2017-02-28) - Journal articleThe catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea ...
(2016-08-01) - Journal itemMonoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets. MAO B structure, function and kinetics ...
Fatty acid-mediated inhibition of metal binding to the multi-metal site on serum albumin : implications for cardiovascular disease (2016) - Journal articleHuman serum albumin (HSA) is the major protein in blood plasma and is responsible for circulatory transport of a range of small molecules including fatty acids, metal ions and drugs. We previously identified the major ...
(2017-01-24) - Journal item
Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+/H+ exchanger (2017-02-15) - Journal articleVacuolar iron transporters (VITs) are a poorly understood family of integral membrane proteins that can function in iron homeostasis via sequestration of labile Fe2+ into vacuolar compartments. Here we report on the ...