Biomedical Sciences Research Complex (BSRC) Research
The Biomedical Sciences Research Complex (BSRC) is an interdisciplinary research centre involving the Schools of Biology, Chemistry, Medicine and Physics and Astronomy. Research at the centre focuses on infection and immunity, chemical biology, DNA repair and enzymology, and is underpinned by world-class facilities for structural biology, proteomics and synthetic chemistry.
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(2017-04) - Journal itemIn a prototypical response to an acute viral infection it would be expected that the adaptive immune response would eliminate all virally infected cells within a few weeks of infection. However many (non-retrovirus) RNA ...
Single-cell studies of IFN-β promoter activation by wildtype and NS1-defective influenza A viruses (2017-03-20) - Journal articleDeletion or truncation of NS1, the principal interferon (IFN) antagonist of influenza viruses, leads to increased IFN induction during influenza virus infection. We have studied activation of the IFN induction cascade by ...
In vitro assay development and HTS of small molecule human ABAD/17β-HSD10 inhibitors as therapeutics in Alzheimer’s Disease (2017-03-17) - Journal articleA major hallmark of Alzheimer’s disease (AD) is the formation of neurotoxic aggregates composed of the amyloid-β peptide (Aβ). Aβ has been recognized to interact with numerous proteins, resulting in pathological changes ...
(2017-02-06) - Journal articleWith lignin-first biorefineries likely to become a reality, controlled depolymerization of high-quality lignin streams to high value products has become a priority. Using bisulfite chemistry, access to a high-β-O-4 content ...
Diphosphane 2,2′-binaphtho[1,8-de][1,3,2]dithiaphosphinine and the easy formation of a stable phosphorus radical cation (2016-04-21) - Journal articleA convenient synthesis route to 2,2’-binaphtho[1,8-de][1,3,2]di-thiaphosphinine (3) was found. Its stable radical cation 3•+ was accessed easily through one-electron oxidation with NOBF4.