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dc.contributor.authorHepburn, Matt S.
dc.contributor.authorWijesinghe, Philip
dc.contributor.authorChin, Lixin
dc.contributor.authorKennedy, Brendan F.
dc.identifier.citationHepburn , M S , Wijesinghe , P , Chin , L & Kennedy , B F 2019 , ' Analysis of spatial resolution in phase-sensitive compression optical coherence elastography ' , Biomedical Optics Express , vol. 10 , no. 3 , pp. 1496-1513 .
dc.identifier.otherPURE: 258254547
dc.identifier.otherPURE UUID: 759f3060-c0ae-446b-b6a6-21ccb34592e3
dc.identifier.otherRIS: urn:5CB153BA5E544692EAE893EE8C2F3A40
dc.identifier.otherORCID: /0000-0002-8378-7261/work/55643850
dc.identifier.otherScopus: 85063879642
dc.identifier.otherWOS: 000460138400035
dc.descriptionFunding: Australian Research Council; the Cancer Council Western Australia; OncoRes Medical; William and Marlene Schrader Trust of the University of Western Australia scholarship.en
dc.description.abstractOptical coherence elastography (OCE) is emerging as a method to image the mechanical properties of tissue on the microscale. However, the spatial resolution, a main advantage of OCE, has not been investigated and is not trivial to evaluate. To address this, we present a framework to analyze resolution in phase-sensitive compression OCE that incorporates the three main determinants of resolution: mechanical deformation of the sample, detection of this deformation using optical coherence tomography (OCT), and signal processing to estimate local axial strain. We demonstrate for the first time, through close correspondence between experiment and simulation of structured phantoms, that resolution in compression OCE is both spatially varying and sample dependent, which we link to the discrepancies between the model of elasticity and the mechanical deformation of the sample. We demonstrate that resolution is dependent on factors such as feature size and mechanical contrast. We believe that the analysis of image formation provided by our framework can expedite the development of compression OCE.
dc.relation.ispartofBiomedical Optics Expressen
dc.rightsCopyright © 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.en
dc.subjectImage metricsen
dc.subjectImage qualityen
dc.subjectMedical imagingen
dc.subjectOptical coherence tomographyen
dc.subjectOptical detectionen
dc.subjectSpatial resolutionen
dc.subjectQC Physicsen
dc.titleAnalysis of spatial resolution in phase-sensitive compression optical coherence elastographyen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.description.statusPeer revieweden

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