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Analysis of spatial resolution in phase-sensitive compression optical coherence elastography

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Hepburn_2019_BOE_spatialresolution_FinalPubVersion.pdf (5.974Mb)
Date
28/02/2019
Author
Hepburn, Matt S.
Wijesinghe, Philip
Chin, Lixin
Kennedy, Brendan F.
Keywords
Image metrics
Image quality
Medical imaging
Optical coherence tomography
Optical detection
Spatial resolution
QC Physics
NDAS
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Abstract
Optical coherence elastography (OCE) is emerging as a method to image the mechanical properties of tissue on the microscale. However, the spatial resolution, a main advantage of OCE, has not been investigated and is not trivial to evaluate. To address this, we present a framework to analyze resolution in phase-sensitive compression OCE that incorporates the three main determinants of resolution: mechanical deformation of the sample, detection of this deformation using optical coherence tomography (OCT), and signal processing to estimate local axial strain. We demonstrate for the first time, through close correspondence between experiment and simulation of structured phantoms, that resolution in compression OCE is both spatially varying and sample dependent, which we link to the discrepancies between the model of elasticity and the mechanical deformation of the sample. We demonstrate that resolution is dependent on factors such as feature size and mechanical contrast. We believe that the analysis of image formation provided by our framework can expedite the development of compression OCE.
Citation
Hepburn , M S , Wijesinghe , P , Chin , L & Kennedy , B F 2019 , ' Analysis of spatial resolution in phase-sensitive compression optical coherence elastography ' , Biomedical Optics Express , vol. 10 , no. 3 , pp. 1496-1513 . https://doi.org/10.1364/BOE.10.001496
Publication
Biomedical Optics Express
Status
Peer reviewed
DOI
https://doi.org/10.1364/BOE.10.001496
ISSN
2156-7085
Type
Journal article
Rights
Copyright © 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
Description
Funding: Australian Research Council; the Cancer Council Western Australia; OncoRes Medical; William and Marlene Schrader Trust of the University of Western Australia scholarship.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/17341

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