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dc.contributor.authorCurrie, Stephen Paul
dc.contributor.authorSillar, Keith Thomas
dc.date.accessioned2019-03-01T00:37:58Z
dc.date.available2019-03-01T00:37:58Z
dc.date.issued2018-03
dc.identifier251555716
dc.identifierda888910-c99f-4ae0-a284-dee8a28cab0c
dc.identifier85042070185
dc.identifier000427348200004
dc.identifier.citationCurrie , S P & Sillar , K T 2018 , ' Developmental changes in spinal neuronal properties, motor network configuration and neuromodulation at free-swimming stages of Xenopus tadpoles ' , Journal of Neurophysiology , vol. 119 , no. 3 , pp. 786-795 . https://doi.org/10.1152/jn.00219.2017en
dc.identifier.issn0022-3077
dc.identifier.otherORCID: /0000-0003-0171-3814/work/64393777
dc.identifier.urihttps://hdl.handle.net/10023/17177
dc.description.abstractWe describe a novel preparation of the isolated brainstem and spinal cord from pro-metamorphic tadpole stages of the South African clawed frog (Xenopus laevis) that permits whole cell patch-clamp recordings from neurons in the ventral spinal cord. Previous research on earlier stages of the same species has provided one of the most detailed understandings of the design and operation of a CPG circuit. Here we have addressed how development sculpts complexity from this more basic circuit. The preparation generates bouts of fictive31 swimming activity either spontaneously or in response to electrical stimulation of the optic tectum, allowing an investigation into how the neuronal properties, activity patterns and neuromodulation of locomotor rhythm generation change during development. We describe an increased repertoire of cellular responses compared to younger larval stages and investigate the cellular level effects of nitrergic neuromodulation as well as the development of a sodium pump-mediated ultra-slow afterhyperpolarisation (usAHP) in these free-swimming larval animals.
dc.format.extent15248843
dc.language.isoeng
dc.relation.ispartofJournal of Neurophysiologyen
dc.subjectDevelopmenten
dc.subjectLocomotionen
dc.subjectNitric oxideen
dc.subjectNeuromodulationen
dc.subjectXenopusen
dc.subjectQP Physiologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNDASen
dc.subject.lccQPen
dc.subject.lccRC0321en
dc.titleDevelopmental changes in spinal neuronal properties, motor network configuration and neuromodulation at free-swimming stages of Xenopus tadpolesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.1152/jn.00219.2017
dc.description.statusPeer revieweden
dc.date.embargoedUntil2019-03-01


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