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dc.contributor.authorCurrie, Stephen Paul
dc.contributor.authorSillar, Keith Thomas
dc.identifier.citationCurrie , S P & Sillar , K T 2018 , ' Developmental changes in spinal neuronal properties, motor network configuration and neuromodulation at free-swimming stages of Xenopus tadpoles ' , Journal of Neurophysiology , vol. 119 , no. 3 , pp. 786-795 .
dc.identifier.otherPURE: 251555716
dc.identifier.otherPURE UUID: da888910-c99f-4ae0-a284-dee8a28cab0c
dc.identifier.otherScopus: 85042070185
dc.identifier.otherWOS: 000427348200004
dc.identifier.otherORCID: /0000-0003-0171-3814/work/64393777
dc.description.abstractWe describe a novel preparation of the isolated brainstem and spinal cord from pro-metamorphic tadpole stages of the South African clawed frog (Xenopus laevis) that permits whole cell patch-clamp recordings from neurons in the ventral spinal cord. Previous research on earlier stages of the same species has provided one of the most detailed understandings of the design and operation of a CPG circuit. Here we have addressed how development sculpts complexity from this more basic circuit. The preparation generates bouts of fictive31 swimming activity either spontaneously or in response to electrical stimulation of the optic tectum, allowing an investigation into how the neuronal properties, activity patterns and neuromodulation of locomotor rhythm generation change during development. We describe an increased repertoire of cellular responses compared to younger larval stages and investigate the cellular level effects of nitrergic neuromodulation as well as the development of a sodium pump-mediated ultra-slow afterhyperpolarisation (usAHP) in these free-swimming larval animals.
dc.relation.ispartofJournal of Neurophysiologyen
dc.rights© 2018, American Physiological Society. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at
dc.subjectNitric oxideen
dc.subjectQP Physiologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleDevelopmental changes in spinal neuronal properties, motor network configuration and neuromodulation at free-swimming stages of Xenopus tadpolesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.description.statusPeer revieweden

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