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Crosstalk between zinc and fatty acids in plasma
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dc.contributor.author | Coverdale, James P. C. | |
dc.contributor.author | Khazaipoul, Siavash | |
dc.contributor.author | Arya, Swati | |
dc.contributor.author | Stewart, Alan J. | |
dc.contributor.author | Blindauer, Claudia A | |
dc.date.accessioned | 2019-02-18T13:30:08Z | |
dc.date.available | 2019-02-18T13:30:08Z | |
dc.date.issued | 2019-04 | |
dc.identifier | 255949100 | |
dc.identifier | b248a1ef-ea7b-414f-bb9d-2815e82b2185 | |
dc.identifier | 85057052491 | |
dc.identifier | 000459366300008 | |
dc.identifier.citation | Coverdale , J P C , Khazaipoul , S , Arya , S , Stewart , A J & Blindauer , C A 2019 , ' Crosstalk between zinc and fatty acids in plasma ' , Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids , vol. 1864 , no. 4 , pp. 532-542 . https://doi.org/10.1016/j.bbalip.2018.09.007 | en |
dc.identifier.issn | 1388-1981 | |
dc.identifier.uri | https://hdl.handle.net/10023/17086 | |
dc.description | This work was supported by the Leverhulme Trust (grant ref. RPG-2017-214), BBSRC (grant ref. BB/J006467/1) and the British Heart Foundation (grant refs. PG/15/9/31270 and FS/15/42/31556). | en |
dc.description.abstract | In mammalian blood plasma, serum albumin acts as a transport protein for free fatty acids, other lipids and hydrophobic molecules including neurodegenerative peptides, and essential metal ions such as zinc to allow their systemic distribution. Importantly, binding of these chemically extremely diverse entities is not independent, but linked allosterically. One particularly intriguing allosteric link exists between free fatty acid and zinc binding. Albumin thus mediates crosstalk between energy status/metabolism and organismal zinc handling. In recognition of the fact that even small changes in extracellular zinc concentration and speciation modulate the function of many cell types, the albumin-mediated impact of free fatty acid concentration on zinc distribution may be significant for both normal physiological processes including energy metabolism, insulin activity, heparin neutralisation, blood coagulation, and zinc signalling, and a range of disease states, including metabolic syndrome, cardiovascular disease, myocardial ischemia, diabetes, and thrombosis. | |
dc.format.extent | 11 | |
dc.format.extent | 1423133 | |
dc.language.iso | eng | |
dc.relation.ispartof | Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids | en |
dc.subject | Zinc | en |
dc.subject | Non-esterified fatty acids | en |
dc.subject | Plasma | en |
dc.subject | Serum | en |
dc.subject | Albumin | en |
dc.subject | QD Chemistry | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QD | en |
dc.title | Crosstalk between zinc and fatty acids in plasma | en |
dc.type | Journal item | en |
dc.contributor.sponsor | The Leverhulme Trust | en |
dc.contributor.sponsor | BBSRC | en |
dc.contributor.sponsor | British Heart Foundation | en |
dc.contributor.sponsor | British Heart Foundation | en |
dc.contributor.institution | University of St Andrews. Cellular Medicine Division | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis | en |
dc.identifier.doi | https://doi.org/10.1016/j.bbalip.2018.09.007 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | RPG-2017-214 | en |
dc.identifier.grantnumber | BB/J006467/1 | en |
dc.identifier.grantnumber | PG/15/9/31270 | en |
dc.identifier.grantnumber | FS/15/42/31556 | en |
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