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dc.contributor.authorCoverdale, James P. C.
dc.contributor.authorKhazaipoul, Siavash
dc.contributor.authorArya, Swati
dc.contributor.authorStewart, Alan J.
dc.contributor.authorBlindauer, Claudia A
dc.identifier.citationCoverdale , J P C , Khazaipoul , S , Arya , S , Stewart , A J & Blindauer , C A 2019 , ' Crosstalk between zinc and fatty acids in plasma ' , Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids , vol. 1864 , no. 4 , pp. 532-542 .
dc.identifier.otherPURE: 255949100
dc.identifier.otherPURE UUID: b248a1ef-ea7b-414f-bb9d-2815e82b2185
dc.identifier.otherScopus: 85057052491
dc.identifier.otherWOS: 000459366300008
dc.descriptionThis work was supported by the Leverhulme Trust (grant ref. RPG-2017-214), BBSRC (grant ref. BB/J006467/1) and the British Heart Foundation (grant refs. PG/15/9/31270 and FS/15/42/31556).en
dc.description.abstractIn mammalian blood plasma, serum albumin acts as a transport protein for free fatty acids, other lipids and hydrophobic molecules including neurodegenerative peptides, and essential metal ions such as zinc to allow their systemic distribution. Importantly, binding of these chemically extremely diverse entities is not independent, but linked allosterically. One particularly intriguing allosteric link exists between free fatty acid and zinc binding. Albumin thus mediates crosstalk between energy status/metabolism and organismal zinc handling. In recognition of the fact that even small changes in extracellular zinc concentration and speciation modulate the function of many cell types, the albumin-mediated impact of free fatty acid concentration on zinc distribution may be significant for both normal physiological processes including energy metabolism, insulin activity, heparin neutralisation, blood coagulation, and zinc signalling, and a range of disease states, including metabolic syndrome, cardiovascular disease, myocardial ischemia, diabetes, and thrombosis.
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipidsen
dc.rightsCopyright © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (
dc.subjectNon-esterified fatty acidsen
dc.subjectQD Chemistryen
dc.titleCrosstalk between zinc and fatty acids in plasmaen
dc.typeJournal itemen
dc.contributor.sponsorThe Leverhulme Trusten
dc.contributor.sponsorBritish Heart Foundationen
dc.contributor.sponsorBritish Heart Foundationen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.description.statusPeer revieweden

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