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Crosstalk between zinc and fatty acids in plasma

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Coverdale_2018_BBA_Crosstalk_CC.pdf (1.357Mb)
Date
04/2019
Author
Coverdale, James P. C.
Khazaipoul, Siavash
Arya, Swati
Stewart, Alan J.
Blindauer, Claudia A
Funder
The Leverhulme Trust
BBSRC
British Heart Foundation
British Heart Foundation
Grant ID
RPG-2017-214
BB/J006467/1
PG/15/9/31270
FS/15/42/31556
Keywords
Zinc
Non-esterified fatty acids
Plasma
Serum
Albumin
QD Chemistry
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Abstract
In mammalian blood plasma, serum albumin acts as a transport protein for free fatty acids, other lipids and hydrophobic molecules including neurodegenerative peptides, and essential metal ions such as zinc to allow their systemic distribution. Importantly, binding of these chemically extremely diverse entities is not independent, but linked allosterically. One particularly intriguing allosteric link exists between free fatty acid and zinc binding. Albumin thus mediates crosstalk between energy status/metabolism and organismal zinc handling. In recognition of the fact that even small changes in extracellular zinc concentration and speciation modulate the function of many cell types, the albumin-mediated impact of free fatty acid concentration on zinc distribution may be significant for both normal physiological processes including energy metabolism, insulin activity, heparin neutralisation, blood coagulation, and zinc signalling, and a range of disease states, including metabolic syndrome, cardiovascular disease, myocardial ischemia, diabetes, and thrombosis.
Citation
Coverdale , J P C , Khazaipoul , S , Arya , S , Stewart , A J & Blindauer , C A 2019 , ' Crosstalk between zinc and fatty acids in plasma ' , Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids , vol. 1864 , no. 4 , pp. 532-542 . https://doi.org/10.1016/j.bbalip.2018.09.007
Publication
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.bbalip.2018.09.007
ISSN
1388-1981
Type
Journal item
Rights
Copyright © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Description
This work was supported by the Leverhulme Trust (grant ref. RPG-2017-214), BBSRC (grant ref. BB/J006467/1) and the British Heart Foundation (grant refs. PG/15/9/31270 and FS/15/42/31556).
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/17086

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