Multi-part balanced incomplete-block designs
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We consider designs for cancer trials which allow each medical centre to treat only a limited number of cancer types with only a limited number of drugs. We specify desirable properties of these designs, and prove some consequences. Then we give several different constructions. Finally we generalize this to three or more factors, such as biomarkers.
Bailey , R A & Cameron , P J 2019 , ' Multi-part balanced incomplete-block designs ' Statistical Papers , vol. 60 , no. 2 , pp. 55-76 . https://doi.org/10.1007/s00362-018-01071-x
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