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Erythritol attenuates postprandial blood glucose by inhibiting α-glucosidase
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dc.contributor.author | Wen, Huaixiu | |
dc.contributor.author | Tang, Bowen | |
dc.contributor.author | Stewart, Alan J. | |
dc.contributor.author | Tao, Yanduo | |
dc.contributor.author | Shao, Yun | |
dc.contributor.author | Cui, Yulei | |
dc.contributor.author | Yue, Huilan | |
dc.contributor.author | Pei, Jinjin | |
dc.contributor.author | Liu, Zenggen | |
dc.contributor.author | Mei, Lijuan | |
dc.contributor.author | Yu, Ruitao | |
dc.contributor.author | Jiang, Lei | |
dc.date.accessioned | 2019-01-23T00:33:48Z | |
dc.date.available | 2019-01-23T00:33:48Z | |
dc.date.issued | 2018-02-14 | |
dc.identifier | 252180879 | |
dc.identifier | 6c57e444-41f2-40ea-b55d-52c0aa0d5f9a | |
dc.identifier | 85042022718 | |
dc.identifier | 000425474000013 | |
dc.identifier.citation | Wen , H , Tang , B , Stewart , A J , Tao , Y , Shao , Y , Cui , Y , Yue , H , Pei , J , Liu , Z , Mei , L , Yu , R & Jiang , L 2018 , ' Erythritol attenuates postprandial blood glucose by inhibiting α-glucosidase ' , Journal of Agricultural and Food Chemistry , vol. 66 , no. 6 , pp. 1401-1407 . https://doi.org/10.1021/acs.jafc.7b05033 | en |
dc.identifier.issn | 0021-8561 | |
dc.identifier.other | ORCID: /0000-0003-4580-1840/work/60195785 | |
dc.identifier.uri | https://hdl.handle.net/10023/16916 | |
dc.description | This work was supported by grants from Natural Science Foundation of Qinghai (No. 2016-ZJ-942Q), West Light Foundation of the Chinese Academy of Sciences (No. Y629071211), National Natural Science Foundation of China (No. 31701243), International Cooperative Projects of Qinghai province (No. 2017-HZ-811), Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Program of Chinese Academy of Sciences (No. ZSTH-027), Major Special Science and Technology Projects in Qinghai Province (2014-GX-A3A-01). | en |
dc.description.abstract | Diabetes mellitus (DM) is a serious metabolic disorder where impaired postprandial blood glucose regulation often leads to severe health complications. The natural chemical, erythritol is a C4 polyol approved by FDA for use as a sweetener. Here we examined a potential role for erythritol in the control of postprandial blood glucose levels in DM. An anti-postprandial hyperglycemia effect upon erythritol administration (500 mg kg-1) was demonstrated in alloxan-induced DM model mice by monitoring changes in blood glucose after intragastric administration of drugs and starch. We also found that erythritol most likely exerts its anti-postprandial hyperglycemic activities by inhibiting α-glucosidase in a competitive manner. This was supported by enzyme activity assays and molecular modelling experiments. In the latter experiments it was possible to successful dock erythritol into the catalytic pocket of α-glucosidase, with the resultant interaction likely to be driven by electrostatic interactions involving Asp 215, Asp69 and Arg446 residues. This study suggests that erythritol may not only serve as a glucose substitute but may also be a useful agent in the treatment of diabetes mellitus to help manage postprandial blood glucose levels. | |
dc.format.extent | 7 | |
dc.format.extent | 1080386 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry | en |
dc.subject | Diabetes mellitus | en |
dc.subject | Postprandial blood glucose | en |
dc.subject | Erythritol | en |
dc.subject | α-glucosidase | en |
dc.subject | RA0421 Public health. Hygiene. Preventive Medicine | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RA0421 | en |
dc.subject.lcc | QD | en |
dc.title | Erythritol attenuates postprandial blood glucose by inhibiting α-glucosidase | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Cellular Medicine Division | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.1021/acs.jafc.7b05033 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2019-01-23 |
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