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Advances in the synthesis of nitroxide radicals for use in biomolecule spin labelling
Item metadata
dc.contributor.author | Haugland, Marius | |
dc.contributor.author | Lovett, Janet Eleanor | |
dc.contributor.author | Anderson, Edward | |
dc.date.accessioned | 2018-12-01T00:50:35Z | |
dc.date.available | 2018-12-01T00:50:35Z | |
dc.date.issued | 2018-02-07 | |
dc.identifier | 251734603 | |
dc.identifier | aa80cea5-291e-44d2-890f-dc2d9d246578 | |
dc.identifier | 85041406434 | |
dc.identifier | 000424136900002 | |
dc.identifier.citation | Haugland , M , Lovett , J E & Anderson , E 2018 , ' Advances in the synthesis of nitroxide radicals for use in biomolecule spin labelling ' , Chemical Society Reviews , vol. 47 , no. 3 , pp. 668-680 . https://doi.org/10.1039/C6CS00550K | en |
dc.identifier.issn | 0306-0012 | |
dc.identifier.uri | https://hdl.handle.net/10023/16602 | |
dc.description | Funding: UK EPSRC (EP/L022044/1), and the Royal Society for a University Research Fellowship (JEL). | en |
dc.description.abstract | EPR spectroscopy is an increasingly useful analytical tool to probe biomolecule structure, dynamic behaviour, and interactions. Nitroxide radicals are the most commonly used radical probe in EPR experiments, and many methods have been developed for their synthesis, as well as incorporation into biomolecules using site-directed spin labelling. In this Tutorial Review, we discuss the most practical methods for the synthesis of nitroxides, focusing on the tunability of their structures, the manipulation of their sidechains into spin labelling handles, and their installation into biomolecules. | |
dc.format.extent | 1596233 | |
dc.language.iso | eng | |
dc.relation.ispartof | Chemical Society Reviews | en |
dc.subject | Nitroxide spin labels | en |
dc.subject | EPR spectroscopy | en |
dc.subject | Chemical synthesis | en |
dc.subject | QC Physics | en |
dc.subject | QD Chemistry | en |
dc.subject | QH301 Biology | en |
dc.subject.lcc | QC | en |
dc.subject.lcc | QD | en |
dc.subject.lcc | QH301 | en |
dc.title | Advances in the synthesis of nitroxide radicals for use in biomolecule spin labelling | en |
dc.type | Journal item | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | The Royal Society | en |
dc.contributor.institution | University of St Andrews. School of Physics and Astronomy | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1039/C6CS00550K | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2018-12-01 | |
dc.identifier.grantnumber | EP/L022044/1 | en |
dc.identifier.grantnumber | UF090121 | en |
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