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dc.contributor.authorRisinggård, Helene Kjær
dc.contributor.authorCooil, Simon
dc.contributor.authorMazzola, Federico
dc.contributor.authorHu, Di
dc.contributor.authorKjærvik, Marit
dc.contributor.authorØstli, Elise Ramleth
dc.contributor.authorPatil, Nilesh
dc.contributor.authorPreobrajenski, Alexei
dc.contributor.authorEvans, D. Andrew
dc.contributor.authorBreiby, Dag W.
dc.contributor.authorTrinh, Thuat T.
dc.contributor.authorWells, Justin W.
dc.identifier.citationRisinggård , H K , Cooil , S , Mazzola , F , Hu , D , Kjærvik , M , Østli , E R , Patil , N , Preobrajenski , A , Evans , D A , Breiby , D W , Trinh , T T & Wells , J W 2018 , ' Degradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfaces ' , Applied Surface Science , vol. 435 , pp. 1213-1219 .
dc.identifier.otherRIS: urn:A2C4A2F80774B876136CC4229B2C4013
dc.descriptionThis research was supported in part with computational resources at NTNU provided by NOTUR (project nn9331k). NP and DWB acknowledge The Research Council of Norway for the financial support through M-ERA.NET project RADESOL under the European Union's seventh framework programme (FP/2007-2013), grant agreement no. 234648/O70.en
dc.description.abstractThe degradation of the chemotherapy drug 5-Fluorouracil by a non-pristine metal surfaces is studied. Using Density Functional Theory, X-ray Photoelectron Spectroscopy and X-ray Absorption Spectroscopy we show that the drug is entirely degraded by medical-grade silver surfaces, already at body temperature, and that all of the fluorine has left the molecule, presumably as HF. Remarkably, this degradation is even more severe than that reported previously for 5-Fluorouracil on a pristine monocrystalline silver surface (in which case 80% of the drug reacted at body temperature) Mazzola et al. (2015). We conclude that the observed reaction is due to a reaction pathway, driven by H to F attraction between molecules on the surface, which results in the direct formation of HF; a pathway which is favoured when competing pathways involving reactive Ag surface sites are made unavailable by environmental contamination. Our measurements indicate that realistically cleaned, non-pristine silver alloys, which are typically used in medical applications, can result in severe degradation of 5-Fluorouracil, with the release of HF – a finding which may have important implications for the handling of chemotherapy drugs.
dc.relation.ispartofApplied Surface Scienceen
dc.subjectSurface scienceen
dc.subjectQC Physicsen
dc.subjectTP Chemical technologyen
dc.titleDegradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfacesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.description.statusPeer revieweden

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