Degradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfaces
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The degradation of the chemotherapy drug 5-Fluorouracil by a non-pristine metal surfaces is studied. Using Density Functional Theory, X-ray Photoelectron Spectroscopy and X-ray Absorption Spectroscopy we show that the drug is entirely degraded by medical-grade silver surfaces, already at body temperature, and that all of the fluorine has left the molecule, presumably as HF. Remarkably, this degradation is even more severe than that reported previously for 5-Fluorouracil on a pristine monocrystalline silver surface (in which case 80% of the drug reacted at body temperature) Mazzola et al. (2015). We conclude that the observed reaction is due to a reaction pathway, driven by H to F attraction between molecules on the surface, which results in the direct formation of HF; a pathway which is favoured when competing pathways involving reactive Ag surface sites are made unavailable by environmental contamination. Our measurements indicate that realistically cleaned, non-pristine silver alloys, which are typically used in medical applications, can result in severe degradation of 5-Fluorouracil, with the release of HF – a finding which may have important implications for the handling of chemotherapy drugs.
Risinggård , H K , Cooil , S , Mazzola , F , Hu , D , Kjærvik , M , Østli , E R , Patil , N , Preobrajenski , A , Evans , D A , Breiby , D W , Trinh , T T & Wells , J W 2018 , ' Degradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfaces ' , Applied Surface Science , vol. 435 , pp. 1213-1219 . https://doi.org/10.1016/j.apsusc.2017.11.221
Applied Surface Science
© 2017 Elsevier B.V. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.apsusc.2017.11.221
DescriptionThis research was supported in part with computational resources at NTNU provided by NOTUR (project nn9331k). NP and DWB acknowledge The Research Council of Norway for the financial support through M-ERA.NET project RADESOL under the European Union's seventh framework programme (FP/2007-2013), grant agreement no. 234648/O70.
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