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dc.contributor.authorMitchell, John B. O.
dc.date.accessioned2018-10-26T23:49:43Z
dc.date.available2018-10-26T23:49:43Z
dc.date.issued2017-12
dc.identifier.citationMitchell , J B O 2017 , ' Enzyme function and its evolution ' , Current Opinion in Structural Biology , vol. 47 , pp. 151-156 . https://doi.org/10.1016/j.sbi.2017.10.004en
dc.identifier.issn0959-440X
dc.identifier.otherPURE: 251245583
dc.identifier.otherPURE UUID: ef78f2ca-8ebf-474f-9396-1bc66393438c
dc.identifier.otherScopus: 85032292220
dc.identifier.otherWOS: 000419413700020
dc.identifier.urihttp://hdl.handle.net/10023/16347
dc.description.abstractWith rapid increases over recent years in the determination of protein sequence and structure, alongside knowledge of thousands of enzyme functions and hundreds of chemical mechanisms, it is now possible to combine breadth and depth in our understanding of enzyme evolution. Phylogenetics continues to move forward, though determining correct evolutionary family trees is not trivial. Protein function prediction has spawned a variety of promising methods that offer the prospect of identifying enzymes across the whole range of chemical functions and over numerous species. This knowledge is essential to understand antibiotic resistance, as well as in protein re-engineering and de novo enzyme design.
dc.language.isoeng
dc.relation.ispartofCurrent Opinion in Structural Biologyen
dc.rights© 2017 Elsevier Ltd. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.sbi.2017.10.004en
dc.subjectQH301 Biologyen
dc.subjectQH426 Geneticsen
dc.subjectQD Chemistryen
dc.subjectT-NDASen
dc.subject.lccQH301en
dc.subject.lccQH426en
dc.subject.lccQDen
dc.titleEnzyme function and its evolutionen
dc.typeJournal itemen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1016/j.sbi.2017.10.004
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-10-27


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