Enzyme function and its evolution
Abstract
With rapid increases over recent years in the determination of protein sequence and structure, alongside knowledge of thousands of enzyme functions and hundreds of chemical mechanisms, it is now possible to combine breadth and depth in our understanding of enzyme evolution. Phylogenetics continues to move forward, though determining correct evolutionary family trees is not trivial. Protein function prediction has spawned a variety of promising methods that offer the prospect of identifying enzymes across the whole range of chemical functions and over numerous species. This knowledge is essential to understand antibiotic resistance, as well as in protein re-engineering and de novo enzyme design.
Citation
Mitchell , J B O 2017 , ' Enzyme function and its evolution ' , Current Opinion in Structural Biology , vol. 47 , pp. 151-156 . https://doi.org/10.1016/j.sbi.2017.10.004
Publication
Current Opinion in Structural Biology
Status
Peer reviewed
ISSN
0959-440XType
Journal item
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