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dc.contributor.authorGunn-Moore, Danielle
dc.contributor.authorKaidanovich-Beilin, Oksana
dc.contributor.authorGallego Iradi, Maria Carolina
dc.contributor.authorGunn-Moore, Frank
dc.contributor.authorLovestone, Simon
dc.date.accessioned2018-09-29T23:54:33Z
dc.date.available2018-09-29T23:54:33Z
dc.date.issued2018-02
dc.identifier.citationGunn-Moore , D , Kaidanovich-Beilin , O , Gallego Iradi , M C , Gunn-Moore , F & Lovestone , S 2018 , ' Alzheimer's disease in humans and other animals : a consequence of postreproductive life span and longevity rather than aging ' , Alzheimer's and Dementia , vol. 14 , no. 2 , pp. 195-204 . https://doi.org/10.1016/j.jalz.2017.08.014en
dc.identifier.issn1552-5260
dc.identifier.otherPURE: 251063486
dc.identifier.otherPURE UUID: 8b562d3d-7fd3-4f74-be5c-2bd976386018
dc.identifier.otherScopus: 85031907092
dc.identifier.otherORCID: /0000-0003-3422-3387/work/37446775
dc.identifier.otherWOS: 000424405500009
dc.identifier.urihttp://hdl.handle.net/10023/16109
dc.descriptionResearch in the author’s laboratories is supported by the NIHR, MRC, ARUK, Alzheimer’s Society, Wellcome Trust and the EUen
dc.description.abstractIntroduction Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading to speculation that caloric restriction might extend life span in man. It is our contention that man is already a long-lived organism, specifically with a remarkably high postfertility life span, and that it is this that results in the prevalence of Alzheimer's disease and diabetes. Methods We review evidence for this hypothesis that carries specific predictions including that other animals with exceptionally long postreproductive life span will have increased risk of both diabetes and Alzheimer's disease. Results and Conclusions We present novel evidence that Dolphin, like man, an animal with exceptional longevity, might be one of the very few natural models of Alzheimer's disease.
dc.language.isoeng
dc.relation.ispartofAlzheimer's and Dementiaen
dc.rights© 2017, The Alzheimer's Association. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.jalz.2017.08.014en
dc.subjectLongevityen
dc.subjectInsulin signalingen
dc.subjectAlzheimer's pathologyen
dc.subjectAnimal modelsen
dc.subjectTauen
dc.subjectAmyloiden
dc.subjectGSK-3en
dc.subjectQH301 Biologyen
dc.subjectQH426 Geneticsen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectT-NDASen
dc.subject.lccQH301en
dc.subject.lccQH426en
dc.subject.lccRC0321en
dc.titleAlzheimer's disease in humans and other animals : a consequence of postreproductive life span and longevity rather than agingen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1016/j.jalz.2017.08.014
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-09-30


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