St Andrews Research Repository

St Andrews University Home
View Item 
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  • Register / Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Alzheimer's disease in humans and other animals : a consequence of postreproductive life span and longevity rather than aging

Thumbnail
View/Open
AD_Diabetes_longevity_AAM.pdf (584.3Kb)
Date
02/2018
Author
Gunn-Moore, Danielle
Kaidanovich-Beilin, Oksana
Gallego Iradi, Maria Carolina
Gunn-Moore, Frank
Lovestone, Simon
Keywords
Longevity
Insulin signaling
Alzheimer's pathology
Animal models
Tau
Amyloid
GSK-3
QH301 Biology
QH426 Genetics
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
T-NDAS
SDG 3 - Good Health and Well-being
Metadata
Show full item record
Abstract
Introduction Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading to speculation that caloric restriction might extend life span in man. It is our contention that man is already a long-lived organism, specifically with a remarkably high postfertility life span, and that it is this that results in the prevalence of Alzheimer's disease and diabetes. Methods We review evidence for this hypothesis that carries specific predictions including that other animals with exceptionally long postreproductive life span will have increased risk of both diabetes and Alzheimer's disease. Results and Conclusions We present novel evidence that Dolphin, like man, an animal with exceptional longevity, might be one of the very few natural models of Alzheimer's disease.
Citation
Gunn-Moore , D , Kaidanovich-Beilin , O , Gallego Iradi , M C , Gunn-Moore , F & Lovestone , S 2018 , ' Alzheimer's disease in humans and other animals : a consequence of postreproductive life span and longevity rather than aging ' , Alzheimer's and Dementia , vol. 14 , no. 2 , pp. 195-204 . https://doi.org/10.1016/j.jalz.2017.08.014
Publication
Alzheimer's and Dementia
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.jalz.2017.08.014
ISSN
1552-5260
Type
Journal article
Rights
© 2017, The Alzheimer's Association. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.jalz.2017.08.014
Description
Research in the author’s laboratories is supported by the NIHR, MRC, ARUK, Alzheimer’s Society, Wellcome Trust and the EU
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/16109

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Advanced Search

Browse

All of RepositoryCommunities & CollectionsBy Issue DateNamesTitlesSubjectsClassificationTypeFunderThis CollectionBy Issue DateNamesTitlesSubjectsClassificationTypeFunder

My Account

Login

Open Access

To find out how you can benefit from open access to research, see our library web pages and Open Access blog. For open access help contact: openaccess@st-andrews.ac.uk.

Accessibility

Read our Accessibility statement.

How to submit research papers

The full text of research papers can be submitted to the repository via Pure, the University's research information system. For help see our guide: How to deposit in Pure.

Electronic thesis deposit

Help with deposit.

Repository help

For repository help contact: Digital-Repository@st-andrews.ac.uk.

Give Feedback

Cookie policy

This site may use cookies. Please see Terms and Conditions.

Usage statistics

COUNTER-compliant statistics on downloads from the repository are available from the IRUS-UK Service. Contact us for information.

© University of St Andrews Library

University of St Andrews is a charity registered in Scotland, No SC013532.

  • Facebook
  • Twitter