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Incorporation of [2H1]-(1R,2R)- and [2H1]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus
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dc.contributor.author | Feng, Xuan | |
dc.contributor.author | Al Maharik, Nawaf | |
dc.contributor.author | Bartholome, Axel | |
dc.contributor.author | Janso, Jeffrey E. | |
dc.contributor.author | Reilly, Usa | |
dc.contributor.author | O'Hagan, David | |
dc.date.accessioned | 2018-09-10T23:35:41Z | |
dc.date.available | 2018-09-10T23:35:41Z | |
dc.date.issued | 2017-10-14 | |
dc.identifier | 251138351 | |
dc.identifier | 453a7bc9-76fd-4fb5-8896-05bfa2564447 | |
dc.identifier | 85030558588 | |
dc.identifier | 000412826500002 | |
dc.identifier.citation | Feng , X , Al Maharik , N , Bartholome , A , Janso , J E , Reilly , U & O'Hagan , D 2017 , ' Incorporation of [ 2 H 1 ]-(1R,2R)- and [ 2 H 1 ]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus ' , Organic & Biomolecular Chemistry , vol. 15 , no. 38 , pp. 8006-8008 . https://doi.org/10.1039/C7OB02163A | en |
dc.identifier.issn | 1477-0520 | |
dc.identifier.other | Bibtex: urn:4965efcd84875bbcf0ed861e0a35a7fe | |
dc.identifier.other | ORCID: /0000-0002-0510-5552/work/68281273 | |
dc.identifier.uri | https://hdl.handle.net/10023/16002 | |
dc.description | The authors thank the Chinese Scholarship Council for Ph.D Studentship support (to XF). | en |
dc.description.abstract | Deuterium incorporations from [2H1]-(1R,2R) and [2H1]-(1S,2R) glycerols into the fluorine containing antibiotic nucleocidin, in Streptomyces calvus indicate that one deuterium atom is incorporated at the C-5′ site of nucleocidin from each of these isotopomers of glycerol. Two deuteriums become incorporated at C-5′ of nucleocidin after a feeding experiment with [2H5]-glycerol. These observations indicate that there is no obligate oxidation of the pro-R hydroxymethyl group of glycerol as it progresses through the pentose phosphate pathway and becomes incorporated into the fluorinated antibiotic. | |
dc.format.extent | 634513 | |
dc.language.iso | eng | |
dc.relation.ispartof | Organic & Biomolecular Chemistry | en |
dc.subject | QD Chemistry | en |
dc.subject | QH301 Biology | en |
dc.subject | NDAS | en |
dc.subject.lcc | QD | en |
dc.subject.lcc | QH301 | en |
dc.title | Incorporation of [2H1]-(1R,2R)- and [2H1]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.1039/C7OB02163A | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2018-09-11 |
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